Combinative Use of Plasmapheresis and Sodium Hypochlorite Infusion in Patients with General Peritonitis Complicated by Multiple Organ Failure

The aim of the investigation is to assess the efficacy of various detoxication techniques in general peritonitis complicated by multiple organ failure and develop a new way of using plasmapheresis.

Materials and Methods. There were studied 111 patients with general peritonitis complicated by multiple organ failure. According to the detoxication techniques used, the patients were divided into 4 groups: in the 1st group (n=26) in complex intensive care there were used indirect electrochemical oxidation of blood in the form of intravenous infusion of sodium hypochlorite; in the 2nd group (n=29) standard plasmapheresis was used; in the 3rd group (n=31) there was used combination of membrane plasmapheresis and sodium hypochlorite according to an original technique; and in the 4th group (n=25) no detoxication was used. The efficacy of detoxication was assessed by general clinical and biochemical blood values, the content of substances of low and medium molecular mass in internal environment.

Results. The combination of plasmapheresis and sodium hypochlorite infused before plasmafilter leads to detoxication effect enhancement of standard plasmapheresis procedure, as well as contributes to the recovery of renal detoxicating function; and it is proved by the dynamics of endogenous intoxication markers in the compared groups.

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Mlinnik R.А., Voennov О.V., Tezyaeva S.А. Combinative Use of Plasmapheresis and Sodium Hypochlorite Infusion in Patients with General Peritonitis Complicated by Multiple Organ Failure. Sovremennye tehnologii v medicine 2011; (4): 84