Infrared Spectral Analysis of a Blood Serum as a Reflection of the Metabolic Process Disturbance Level at Infectious Pathology in Children
The aim of work is a detection of the IR-spectroscopic analysis integrative value correlation with a toxicosis expression degree, stipulated by the metabolic disturbance level.
Materials and Methods. 183 children with different clinical variants of diphtheria, angina, infectious mononucleosis and 30 healthy children at the age of 1 to 14 years were observed. The dried blood serum, prepared for the IR-spectral analysis, was investigated.
Results and discussion. The differences of the spectral analysis conventional mathematical symbol (parameter) numerical meanings at different diseases in children depending on a degree of intoxication expression, characteristic of each disease, as well as on their meanings in healthy children, are revealed. Besides, the substantional differences of numerical meanings are marked at different outcomes of the diphtheria critical forms (the survived and died children). A correlation between the blood serum IR-spectral analysis alterations and a metabolism disturbance level at infectious pathology, defined by the intoxication expression degree, is revealed. It is presumed, that the blood serum IR-spectra reflect a level of metabolic disturbances in the organism, appearing under the influence of infectious agent. These alterations are not specific for any separate disease and reflect the common regularities of the infectious process pathogenesis.
