Syndrome of a Systemic Inflammatory Reaction at the Acute Pancreatitis: Peculiarities of a Molecular Pathophysiology and Possible Ways of Correction

Aim of the given work is a study of the lornoxycam-cyclooxygenase inhibitor influence on the proinflammatory and antiinflammatory cytokine output, stipulated by ligands of the 1st and 2nd type Toll-like receptors (TLR1/2) and the 4th type Toll-like receptors (TLR4), the mononuclear cells of the healthy donor peripheral blood in vitro and in patients with the AP.

Materials and Methods. Influence of a nonsteroid antiinflammatory preparation on a synthesis of the pro-and and antiinflammatory cytokines was assessed in 10 healthy donors and 11 patients with the acute pancreatitis.

Results. A release of the endogenous ligand significant concentrations takes place at the acute pancreatitis as a result of the organism proper cell large number death, which leads to activation of the TLR signal ways, activation of the immune system cell and starts the pro-inflammatory cytokine output. That fact necessitates the preparation with a cytokine-inhibiting activity inclusion into a complex therapy of AP.

Gorsky V.A., Agapov M.A., Kovalchuk E.R., Ovanesyan E.R., Khoreva M.V., Nickonova I.V., Leonenko I.V., Indarockov V.V., Grechenko V.V. Syndrome of a Systemic Inflammatory Reaction at the Acute Pancreatitis: Peculiarities of a Molecular Pathophysiology and Possible Ways of Correction. Sovremennye tehnologii v medicine 2010; (2): 39