Role of the Soluble Differentiated Molecule Structural and Functional Forms in Differential Diagnosis of the Uterus Myoma and Endometrium Cancer
Aim of investigation is a comparative assessment of the peripheral blood soluble differentiated molecule pull structural and functional state of patients with the endometrium cancer and uterus myoma.
Materials and Methods. A serous level of the soluble differentiated molecules CD8, CD25, CD38, CD50, CD54, CD18, oligomeric fractions of the soluble molecules CD8, CD25, CD38, CD50 and CD54, soluble associates CD8—HLA-I, CD18—CD50 and CD18—CD54 was detected in patients with the endometrium cancer and uterus myoma.
Results. The differences in content of the peripheral blood soluble differentiated molecule structural and functional form in patients with the uterus myoma and endometrium cancer are revealed. An increase of the soluble molecule CD38 and CD50 total fraction serous content, as well as the soluble complexes CD8—HLA-I, was observed at the uterus myoma. Besides, a content of the soluble molecule CD50 total fraction correlated with a serous level of the soluble complexes CD18—CD50. A serous content of the soluble molecule CD8 total and oligomeric fractions, oligomeric form of the molecules CD50 and total fraction of the soluble molecules CD54 was increased both at the uterus myoma and endometrium cancer. However, a serous content of the soluble associates CD18—CD54 was increased only at the endometrium cancer.
