Metabolic Activity of Neutrophiles, a Level of Pro-inflammatory Cytokines and Endothelial Dysfunction in Patients with the Ischemic Heart Disease Lethal Outcome
Aim of investigation is a study of the neutrophile metabolic activity, a level of pro-inflammatory cytokines and endothelial dysfunction in patients with IHD as the cardiac death markers.
Materials and Methods. A metabolic activity of neutrophiles was studied in 100 patients with instable stenocardia and myocardial infarction; a content of interleukin-6, the tumor necrosis factor α, the von Villebrand’s factor was detected.
Results. It is established, that the higher levels of interleukin-6 and the von Villebrand’s factor as well as neutrophilia, accompanied by the oxygen active form phagocyte production increase at the background of their antioxidant protection decrease (glutationreductase) and activation of the lipid peroxidation process, have been revealed in patients with a cardiac death at a hospital during a year. A strongly expressed direct correlation (r=0.90; p=0.03) between the von Villebrand’s factor concentration growth and an increase of the oxygen active form output by neutrophiles is found.
