Dynamics of Lipid Peroxidation Under the Effect of Antioxidant Preparations in the Conditions of Experimental Tumour Growth
The aim of the investigation is to study the effect of melatonin (Melaxen) and metformin on the processes of lipid peroxidation (LP) in blood serum and on the tissue of tumours of thin skin in mice in the conditions of tumour growth induced by benzpyrene.
Materials and Methods. In experimental studies endogenous hormone, melatonin, and antidiabetic biguanide metformin have been used to correct carcinogenic effect. The dynamics of LP values has been studied on benzpyrene model of carcinogenesis. LP activity has been assessed by the content of malonic dialdehyde and the activity of catalase.
Results. There has been stated significantly high antioxidant, oncoprotective and geroprotective activity in the preparations under study. The most pronounced effect has been observed in simultaneous use of melatonin and metformin.
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