Integrated Assessment of Cardioprotective Effect of Sevoflurane
The aim of the investigation is to give integrated (clinical, functional, morphological and biochemical) assessment of cardioprotective effect of low-flow anesthesia based on Sevoflurane.
Materials and Methods. There was carried out retro- and prospective analysis of clinical studies of 815 patients who underwent heart surgeries with extracorporeal circulation. All the patients were divided into two groups according to the anesthetic used: 370 patients of first group were given Sevoflurane as the main anesthetic, and Propofol was used in the control group (445 patients).
Results. Sevoflurane has been stated to contribute to favourable cardiac resuscitation after ischemia, reduce the incidence of acute postoperative failure, provide higher values of myocardial contractive function in the post-perfusion period, decrease oxygen consumption by peripheral tissues, and facilitate more adequate microcirculation in myocardium and maintain the ultrastructure of cardiomyocytes. It enables to conclude about a marked cardioprotective effect of Sevoflurane.
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