Predictors of Myocardial Infarction and the Features of Postinfarction Remodelling in Patients with Chronic Obstructive Pulmonary Disease

The aim of the investigation is to determine possible predictors of myocardial infarction (MI) in patients with chronic obstructive pulmonary disease (COPD) and assess the effect of bronchopulmonary pathology on the processes of postinfarction cardial remodelling.

Materials and Methods. 235 patients were examined and divided into three groups. The 1st group (n=70) consisted of patients with MI combined with COPD, the 2nd group (n=39) — MI patients, and the 3rd one (n=126) — COPD patients. To assess the effect of COPD exacerbation on cardial remodelling, the first group was subdivided into 2 subgroups: the patients without COPD exacerbation (n=35) and the patients with COPD signs (n=35).

Conclusion. The presence of COPD has a negative effect on the processes of postinfarction remodelling due to the aggravation of systolic dysfunction of the left ventricle and dilatation of the heart. The exacerbation of bronchopulmonary pathology is the factor that triggers MI, as well as it can be the trigger of acute coronary events resulting from the activation of systemic inflammation.

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Frolov А.G., Nekrasov А.А., Kuznetsov A.N., Shkarin Vl.V. Predictors of Myocardial Infarction and the Features of Postinfarction Remodelling in Patients with Chronic Obstructive Pulmonary Disease. Sovremennye tehnologii v medicine 2011; (4): 66