The Assessment Criteria of Morphological Changes of Duodenal Mucosa in Gastroduodenitis in Follow-up

The aim of the investigation is to determine prognostic criteria of the course of chronic gastroduodenitis in young patients based on the analysis of dysregenerative process in duodenal mucosa in the same patients at school age.

Materials and Methods. There were examined 24 patients with chronic gastroduodenitis (CGD) in exacerbation, aged 7–14 years. And 18–20 years later 20 patients of the same group were examined outpatiently.

Results. The revealed parallels of morphological changes in duodenal mucosa in the same patients in childhood and in adults suggest that the presence of recurrent diffuse inflammatory process characterizing severe duodenitis at school age causes persistent structural changes. The shortening of villi contours, the decrease of crypts volume, and morphometrical confirmation of the monomorphic character of epithelial layer and cellular spectrum of lamina propria taking into account leiomyocyti in the gradient ”villus-crypt” are informative criteria complex that allows suggesting duodenal mucosa atrophy.

1. Kononov A.V. Kletochnoe obnovlenie i mestnyy immunitet v dinamike khronicheskogo vospaleniya. V kn.: Mestnyy immunitet i regeneratsiya slizistykh obolochek [Cell renewal and local immunity in the course of chronic inflammation. In: Local immunity and mucosa regeneration]. Pod red. V.V. Semchenko [V.V. Semchenko (editor)]. Omsk: Izd-vo Tsentr klinicheskoy patologii; 1993; p. 178–191.
2. Potekhin P.P., Pletneva N.B., Shirokova N.Yu., Sokolova I.L., Kuznetsova T.A., Galova E.A. Sposob opredeleniya sostoyaniya regeneratsii slizistoy obolochki tonkoy kishki [The way of determination of intestinal mucosa regeneration condition]. Patent RF №2267999, 2006.
3. Aruin L.I., Kapuller L.L., Isakov V.A. Tonkaya kishka. Funktsional’naya morfologiya. V kn.: Morfologicheskaya diagnostika bolezney zheludka i kishechnika [Small intestine. Functional morphology. In: Morphological diagnosis of gast­ric and intestinal diseases]. Moscow: Izd-vo «Triada Kh»; 1998; p. 301–312.
4. Pletneva N.B. Kliniko-morfofunktsional’nye osobennosti dvenadtsatiperstnoy kishki i lechenie khronicheskikh gastro­duodenitov u detey shkol’nogo vozrasta. Avtoref. dis. … kand. med. nauk [Clinical and morphofunctional characteristics of duodenum and the treatment of chronic gastroduodenites in school-aged children. Abstract of Dissertation for the degree of Candidate of Medical Science]. Kazan; 1988.
5. Potekhin P.P., Paukov V.S. Arh Patol 1997; 2: 68–81.
6. Whitеhead R. Mucosal biopsy of the gastrointestinal tract. Philadelphia: Saunders; 1990; 455 p.
7. Shousha S., Parkins R.A., Bull T.B. Chronic duodenitis with gastric metaplasia: electron microscopic study including comparison with normal. Histopathology 1983; 7: 873–885.
8. Kil’diyarova R.R., Bazhenov E.L. Ross Pediatr Z 2000; 2: 15–18.

Pletnyova N.B., Shirokova N.Y. The Assessment Criteria of Morphological Changes of Duodenal Mucosa in Gastroduodenitis in Follow-up. Sovremennye tehnologii v medicine 2011; (4): 75