Multifactor Estimation of Dynamics of Development Disturbances of Male Reproductive System in Ontogenesis

The aim of the investigation is to study pathogenetic aspects of abnormal sexual maturation in boys in various ontogenesis periods.

Materials and Methods. 35 fetuses with isolated or combined urogenital system pathology were included into the study. A control group consisted of male fetuses with no abnormal development (29 fetuses) resulted from spontaneous or induced abortions and premature deliveries.

Conclusion. Abnormality of gonadal and hormonal sex formation in fetal life was stated to underlie in hypogonadism pathogenesis and other fetal maldevelopment. The etiology of this period of ontogenesis includes pathological conditions of reproductive system of fathers, the assessment and correction of these conditions in the period of preconceptual preparation should be necessary component of primary prevention.

1. Novikov P.V. Rossiyskiy vestnik perinatologii i pediatrii 2010; 1(55): 6–11.
2. Dedov I.I., Kalinchenko S.Yu. Vozrastnoy androgennyy defitsit u muzhchin [Androgen deficiency in aging men]. Moscow: Prakticheskaya meditsina; 2006; 240 p.
3. Artifeksov S.B. Farmakoterapiya v andrologii [Pharmacotherapy in andrology]. Moscow: Meditsinskaya kniga; 2008; 214 p.
4. Gubler E.V. Vychislitel’nye metody analiza i raspoznava­niya patologicheskikh protsessov [Computational methods of analysis and definition of pathological processes]. Moscow: Meditsina; 1978; 294 p.

Artifexova М.S., Artifexov S.B. Multifactor Estimation of Dynamics of Development Disturbances of Male Reproductive System in Ontogenesis. Sovremennye tehnologii v medicine 2011; (4): 117