Comparative Assessment of the Effect of Melatonin and 3-hydroxypyridine Derivative on Hematotoxicity and Antitumour Efficacy of Alkylating Cytostatic in Mice with Lewis Lung Carcinoma

The aim of the investigation is to give comparative assessment of melatonin (Melaxen) and the derivative of 3-hydroxypyridine (Mexidol) effect on hematotoxicity and antitumour efficacy of alkylating cytostatic Cyclophosphan in mice with Lewis lung carcinoma.

Materials and Methods. The experiments were carried out on 80 female mice of C57Bl/6 line, weighing 20–22 g. Cyclophosphan was administered twice at the dosage of 100 mg/kg at 96h intervals intraperitoneally, and Melaxen and Mexidol — intramuscularly at the dosages of 50 and 45 mg/kg respectively, within 14 days. In each group of animals there was assessed hematotoxicity, treatment efficacy by the index of tumour growth inhibition, and antimetastasis effect by an average number of superficial lung metastases per an animal.

Conclusion. Melaxen and Mexidol decrease Cyclophosphan hematotoxicity without reducing its antitumour efficacy in regard to primary tumour node. Cyclophosphan and Melaxen used in combination do not change antimetastasis effect, while the latter is increasing when cytostatic agent is used with Mexidol compared to the administration of Cyclophosphan only.

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Vashurkina I.M., Siprov А.V., Plotnikova N.А. Comparative Assessment of the Effect of Melatonin and 3-hydroxypyridine Derivative on Hematotoxicity and Antitumour Efficacy of Alkylating Cytostatic in Mice with Lewis Lung Carcinoma. Sovremennye tehnologii v medicine 2011; (4): 158