The Role of Forced Auto-oscillations Synchronization of Cell Density of Hyperproliferating Epidermis in Psoriasis Pathogenesis

The aim of the investigation is to explain some clinical and pathogenetic characteristics of the course of the disease based on theoretical analysis of frequency and phase auto-oscillations synchronization of cell density of hyperproliferating epidermis in psoriasis by external periodic force.

Materials and Methods. The objects of the study were original mathematical models of autocrine and paracrine regulation of epidermis proliferation in psoriasis.

Results. The maximum width of auto-oscillations collecting zone of cell density of hyperproliferating epidermis by external periodic force with the same or close period is within the range of 15.9–36.7 days, with three months’ period — within the range of 79.5–99.7 days. The mechanism of covering governs the start of certain dependence of dermatosis onset and exacerbation on monthly periods, season weather changes as well as sudden transition of one meteo-related form into another and the presence of latent period between abrupt climate variation and the next recurrence.

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Laptev М.V. The Role of Forced Auto-oscillations Synchronization of Cell Density of Hyperproliferating Epidermis in Psoriasis Pathogenesis. Sovremennye tehnologii v medicine 2012; (1): 49