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The Effect of Ribomunyl and Licopid on Immunity Indexes in Gastric and Duodenal Ulcer

The Effect of Ribomunyl and Licopid on Immunity Indexes in Gastric and Duodenal Ulcer

Dugina V.V., Shirali Rashmi, Babayan S.R., Lebedeva N.V., Rudakova G.V., Khrulyova N.S.
Key words: eradication, immunomodulators, H. Pylori contamination, Helicobacter pylori, gastric and duodenal ulcer, Т-lymphocytes.
2012, issue 1, page 75.

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The aim of the investigation is to study the effect of immunomodulators Ribomunyl and Licopidin on Helicobacter pylori eradication and cell-mediated immunity indexes in chronic gastric and duodenal ulcer.

Materials and methods. 30 patients with Helicobacter pylori associated gastric and duodenal ulcer were studied, and cell-mediated immunity indexes in 8 conditionally healthy persons were determined. The techniques used were endoscopic, cytomorphological and immunotechnique (indirect immunofluorescence using monoclonal antibodies to differentiation and activation antigen of lymphocytes) (LLC “Sorbent”, Moscow)). The intensity of H. pylori and T-lymphocyte subpopulation (CD4, CD8, CD16, CD95) contamination was determined to study the effect of immunomodulators on eradication and cell-mediated immunity.

Results. The administration of microbial immunomodulators — Ribomunyl and Licopidin — in combination with anti H. pylori therapy results in increasing H. Pylori eradication degree. These drugs have a positive effect on cell-mediated immunity indexes in patients with secondary immunodeficiency due to H. pylori contamination and antimicrobial therapy.

Conclusion. Ribomunyl and Licopidin can be recommended to be administered in combination with eradication scheme from the first day of Helicobacter pylori associated gastric and duodenal ulcer treatment.


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