Histological Response of Oral Mucosa on Fractional Laser Photothermolysis in Animal Experiments

The aim of the investigation is to prove the supposition that gingival treated by fractional laser photothermolysis is able to initiate regeneration of gingival tissues due to the stimulation of fibroblasts formation, new collagen and vascular structure growth, and complete gingival healing.

Materials and Methods. There has been used an original laser system of “Dental Photonics” based on diode laser with wave length of 980 nm generating radiation, with radiation power being up to 20 Watt to perform fractional laser photothermolysis. Each column of microcoagulation was formed in exposure time of 80, 120 or 150 ms. The experiments have been carried out on 18 healthy rabbits. The animals have undergone in vivo laser treatment, and then have been followed up within 90 days.

Results. A single fractional laser photothermolysis procedure with wave length of 980 nm and optimal pulse length of 150 ms was found to induce oral mucosa regeneration till health tissue structure. In healing process, new tissue is characterized by increased blood supply and fibroblasts concentration with no fibrosis signs.

Conclusion. The obtained data enable to consider fractional laser photothermolysis as prospective technique of the treatment of oral soft tissue diseases.

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Gladkova N.D., Feldstein F.I., Karabut М.М., Ostrovskaya Y.V., Snopova L.B., Kiseleva Е.B., Romanos G.E. Histological Response of Oral Mucosa on Fractional Laser Photothermolysis in Animal Experiments. Sovremennye tehnologii v medicine 2012; (3): 7