Prognostic Value of Age for Patients with Early Breast Cancer

Kolyadina I.V., Poddubnaya I.V., van de Velde C.J.H., Kuppen P.J.K., Dekker-Ensink N.G., de Kruijf E., Sajet A., Liefers G.J., Bastiaannet E., Frank G.A., Komov D.V., Ozhereliev A.S., Karseladze A.I., Ermilova V.D., Vishnevskaya Y.V., Makarenko N.P., Teterin K.A., Banov S.M.

Key words: early breast cancer T1N0M0-stage, prognostic significance of patients age.

2012, issue 3, page 31.

Full text

pdf

1672

Abstract
References
How to cite

The aim of the investigation is the study of prognostic significance of age in early breast cancer (T₁N₀M₀-stage) on the basis of large clinical data.

Materials and Methods. In multi-centre study included archival data of patients with early breast cancer (T₁N₀M₀-stage) who had been treated from 1985 to 2009 in Russia (N.N. Blokhin Russian Cancer Research Center of RAMS and Clinic of Russian Medical Academy for Postgraduate Education — 1036 female) and in the Netherlands (Leiden University Medical Center, LUMC — 560 patients). For comparison there were studied the data of Dutch Cancer Database (22196 patients included into National Archive from 1989 to 2009).

Results. Age of patients is an important prognostic factor for early breast cancer: the rate of recurrences is higher in patients 50 years. In analyses was found predominance of patients >50 years in the Netherlands for comparing with Russia and also was shown the growth of age of patients with early breast cancer during the twenty years in both countries.

Theriault R.L., Litton J.K., Mittendorf E.A., Chen H., Meric-Bernstam F., Chavez-Macgregor M., Morrow P.K., Woodward W.A., Sahin A., Hortobagyi G.N., Gonzalez-Angulo A.M. Age and survival estimates in patients who have node-negative T1ab breast cancer by breast cancer subtype. Clin Breast Cancer 2011 Oct; 11(5): 325–231.
Colzani E., Liljegren A., Johansson A.L., Adolfsson J., Hellborg H., Hall P.F., Czene K. Prognosis of patients with breast cancer: causes of death and effects of time since diagnosis, age and tumor characteristics. J Clin Oncol 2011 Oct 20; 29(30): 4014–4021.
Kim I.K., Park S., Hwang H., Lee J.S., Ko S.M., Kim S.I., Park B.W. Clinical significance of age at the time of diagnosis among young breast cancer patients. J Breast Cancer 2011 Dec; 14(4): 314–321.
van de Water W., Bastiaannet E., Hille E.T., Meershoek-Klein K.E.M., Putter H., Seynaeve C.M., Paridaens R., de Craen A.J., Westendorp R.G., Liefers G.J., van de Velde C.J. Age-specific nonpersistence of endocrine therapy in postmenopausal patients diagnosed with hormone receptor-positive breast cancer: a TEAM study analysis. Oncologist 2012; 17(1): 55–63.
Gazet J.C., Sutcliffe R. A randomised trial comparing tamoxifen vs surgery in patients over the age of 70 with operablebreast cancer — final results after 28 years of follow-up. Eur J Surg Oncol 2011 Sep; 37(9): 754–757.