The Significance of Laboratory Indices to Determine the Number of Lesions in Patients with Non-muscle Invasive Urinary Bladder Cancer

The aim of the investigation is to estimate laboratory indices to determine the number of lesions in patients with non-muscle invasive urinary bladder cancer.

Materials and Methods. There were studied 552 patients with non-muscle invasive urinary bladder cancer, who had been treated in Republic Scientific Practical Centre of Oncology and Medical Radiology named after N.N. Alexandrov in 2002–2010 (Republic of Belarus). Modern laboratory techniques (immunoenzyme, immunoturbidity method, spectrofluorometry, ozonation, electron paramagnetic resonance spectrometry) were used to study tumour markers, growth factors, angiogenesis, cell-cell adhesion, endothelial damage, the products of inflammation and oxidative modifications of proteins and lipids in biological fluids (blood serum and plasma, urine). The investigation had been carried out before special treatment was started. The patients were divided into two groups depending on the number of lesions (266 patients with a single mass lesion, and 286 — with multiple mass lesions).

Results. Statistical analysis of the data obtained enabled to reveal four indices from 27 studied parameters (Urinary Bladder Cancer — UBC, Tissue Polypeptide Antigen Specific — TPS, Intercellular Adhesion Molecule — sICAM, Transmembrane HER2-neu receptor — p185) correlating maximally with the number of lesions and minimally — among themselves, and form two regression equations on their basis. The equations make it possible to determine the presence of multiple mass lesions in patients with non-muscle invasive urinary bladder cancer preoperatively, the sensitivity of equations being 81–84%. Thus, clinicians can carry out an additional thorough examination of a patient (photodynamic diagnosis) in due time in order to reveal multifocal tumour growth.

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Derzhavets L.A. The Significance of Laboratory Indices to Determine the Number of Lesions in Patients with Non-muscle Invasive Urinary Bladder Cancer. Sovremennye tehnologii v medicine 2012; (3): 36