.jpg)
Prognostic Significance of Subclinical Atherosclerosis of Arteries for Cardiovascular Risk Identification in Patients with Autoimmune Thyroiditis
The aim of the investigation is to study the state of arteries of elastic and muscular type in patients with autoimmune thyroiditis and subclinical hypothyroidism to reveal potential factors of cardiovascular risk.
Materials and Methods. There have been studied three groups of patients, each group consisting of 29 females: 1st — control group, with no abnormalities, 2nd — with autoimmune thyroiditis and euthyroid status, 3rd — with autoimmune thyroiditis and subclinical hypothyroidism. There have been estimated hormonal status (ТТГ, Т4, Т3), antibody level to thyroglobulin and thyroid peroxydase, endothelial function and arterial stiffness.
Results. In subclinical hypothyroidism there is significant decrease of endothelial function of brachial artery, with normal indices of non-endothelium dependent vasodilation; arterial wall stiffness and endothelial dysfunction increase, that is determined by a number of factors including the levels of T3, T4, thyrotropic hormone, lipid profile, and arterial pressure. The level of systemic arterial pressure can be of great concern in the increase of arterial stiffness if there are no marked changes of lipid spectrum. The obtained data indicate the negative effect of even minimal thyroid function on vessel condition that can contribute to the increase of cardiovascular risk along with lipid spectrum disorders in this group of patients.
- Sych Yu.P., Kalashnikova V.Yu. et al. Klin Med — Clinical Medicine 2003; 11: 4–9.
- Biondi B. Cardiovascular effects of mild hypothyroidism. Thyroid 2007; 17(7): 625–630.
- Owen P.J., Rajiv C., Vinereanu D., Mathew T., Fraser A.G., Lazarus J.H. Subclinical hypothyroidism, arterial stiffness, and myocardial reserve. J Clin Endocrinol Metab 2006; 91(6): 2126–2132.
- Dagre A.G., Lekakis J.P., Papaioannou T.G., Papamichael C.M., Koutras D.A., Stamatelopoulos S.F., Alevizaki M. Arterial stiffness is increased in subjects with hypothyroidism. Int J Cardiol 2005; 103(1): 1–6.
- Rodondi N., den Elzen W.P., Bauer D.C., Cappola A.R., Razvi S., Walsh J.P. et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA 2010 Sep 22; 304(12): 1365–1374.
- Gussekloo J., van Exel E., de Craen A.J., Meinders A.E., Frolich M., Westendorp R.G. Thyroid function, activities of daily living and survival in extreme old age: the ‘Leiden 85-plus Study’. Ned Tijdschr Geneeskd 2006 Jan 14; 150(2): 90–96.
- Kuntsevich G.I. Ul’trazvukovaya diagnostika — Diagnostic Ultrasound 2000; 3: 71–77.
- Ivanova O.V., Balakhonova T.V., Soboleva G.N. et al. Kardiologia — Cardiology 1997; 7: 41–46.
- Zateyshchikov A.A., Zateyshchikov D.A. Kardiologia — Cardiology 1998; 20: 426–432.
- Celermajer D.S., Sorensen K.E., Gooch V.M. et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111–1115.
- Pignoli P., Tremoli E., Poli A., Oreste P., Paoletti R. Intimal plus medial thickness of arterial wall: the direct measurement with ultrasound imaging. Circulation 1986; 74: 1339–1408.
- Harloff А. Combined measurement of carotid stiffness and intima-media thickness improves prediction of complex aortic plaques in patients with ischemic stroke. Stroke 2006; 37: 2708–2712.
- Roman M.J. et al. Impact of arterial stiffening on left ventricular structure. Hypertension 2000; 36: 489–494.
- Schmidt-Trucksass А. et al. Structural, functional and hemodynamic changes of the common carotid artery with age in male subjects. Arterioscler Thromb Vasc Biol 1999; 19: 1091–1097.
- Selzer R.H. et al. Improved common carotid elasticity and intima-media thickness measurements from computer analysis of sequential ultrasound frames. Atherosclerosis 2001; 154(1): 185–193.
