The Estimation of a Virus Component for Diagnosis and Treatment of Oral Inflammatory Diseases

The aim of the investigation is to offer and prove the necessity of an estimation of a virus component for the diagnosis and treatment of oral inflammatory diseases.

Materials and Methods. There were examined oral cavity of the group of almost healthy men (n=55), aged 20–35 years, and women (n=50), aged 20–36 years; as well as 45 men, aged 20–40 years with the diagnosis of periodontitis and gingivitis.
Polymerase chain reaction in real time, and enzyme multiple immunoassay were used to diagnose infectious agents.

Results. Bacteria play the leading part in the development of oral chronic inflammation (periodontitis), the role of viruses is more significant in acute inflammation. The most common are virus-bacterial associations aggravating inflammation course. Microflora has no specific character. The changes are more marked in severe immune deficiency. Active asymptomatic oral herpesvirus infection in chronic periodontitis leads to the decrease of local protective reaction. More effective results of the treatment of periodontitis and gingivitis were stated to be statistically significant (p<0.001) if the treatment included antiviral therapy along oral cavity sanation from bacterial agents, and immunomodulating therapy, compared to conventional therapy without antivirals.

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Shevchenko Е.А., Uspenskaya O.A., Kondyurov I.M., Kurylev V.V., Rossohin V.F. The Estimation of a Virus Component for Diagnosis and Treatment of Oral Inflammatory Diseases. Sovremennye tehnologii v medicine 2012; (3): 96