Chronic Recurrent Herpetic Stomatitis as Immune System Disease

There have been considered modern views on pathogenesis of chronic recurrent herpetic stomatitis. There has been demonstrated that the pathology can be characterized as chronic multi-factor recurrent process with the signs of combined secondary immunodeficiency with the damage of T- and B-components of immunity, suppression of functional activity of NK-cells and monocytic and macrophage cells, as well as with the damage of immunoregulatory changes in immune system. In any of these cases herpes simplex virus has the chance to survive, mutate, and, finally, be latent.

1. Molochkov V.A. Genital’nyy gerpes: klinika, diagnostika, lechenie i profilaktika [Herpes genitalis: clinical picture, diagnosis, treatment and prevention]. Moscow; 2005; 120 p.
2. Nabi-Zade K.T. Kompleksnaya protivovirusnaya i immunozamestitel’naya terapiya sochetannoy gerpeticheskoy infektsii. Avtoref. … kand. med. nauk [Complex anti-viral and immunosupportive therapy of combined herpetic infection. Abstract of Dissertation for the degree of Candidate of Medical Science]. Moscow; 2003.
3. Uchaykin V.F., Shamshaeva V.F. Vaktsinoprofilaktika. Nastoyashchee i budushchee [Vaccine prophylaxis. Present and future]. Moscow: GEOTAR-MED; 2001.
4. Kirchner J.T. Sexually transmitted diseases in women. Chlamydia trachomatis and herpes simplex infections. Postgrad Med 2000 Jan; 107(1): 55–58, 61–65.
5. Red'kin Yu.V., Odokienko A.Yu. Ginekologiya — Gynecology 2004; 6(6): 1–6.
6. Karimova I.M. Gerpesvirusnaya infektsiya. Diagnostika, klinika, lechenie [Herpesvirus infection. Diagnostics, clinical picture, treatment]. Moscow: Meditsinskoe informatsionnoe agentstvo; 2004; 120 p.
7. Borovskiy E.V., Mashkilleyson A.L. Zabolevaniya slizistoy obolochki polosti rta i gub [Diseasis of oral and labial mucosa]. Moscow; 1984: 116–118.
8. Malkin J.E., Stanberry L. Recommendations from the IHMF Management strategios Workshop. Cambridge; 2004.
9. Vald A., Zeh J., Selke S., Warren T., Ryncarz A.J., Ashley R., Krieger J.N., Corey L. Re­activation of genital herpes simplex virus type 2 infection in asymptomatic seroposi­tive persons. N Engl J Med 2000 Mar; 342: 844–850.
10. Zhukova O.B., Ryazantseva N.V., Novitskiy V.V. Byulleten’ sibirskoy meditsiny — Bulletin of Siberian medicine 2003; 4: 113–120.
11. Mikloska Z., Rickholdt M., Ghadiminejad I., Dunckley H., Denis M., Cunningham A.L. Monophosphoryl lipid A and QS21 increase CDS T lymphocyte cytotoxicity to herpes simplex virus-2 infected cell proteins 4 and 27 through IFN-gamma and IL-12 produc­tion. J Immunol 2000; 164(10): 5167–5176.
12. Kawa K. EBV-associated diseases in humans. Int J Hematologia 2000; 71: 108–117.
13. Miller R.L., Tomai M.A., Harrison C.J., Bernstein D.I. Immunomodulation as a treatment strategy for genital herpes: review of the evidence. International immunopharmacology 2002; 2(4): 443–451.
14. Tereshchenko A.V., Solov'ev A.M., Zadionchenko E.V. Ross Z Koznyh Vener Bolezn — Russian Journal of Skin and Veneral Diseases 2007; 2: 10–13.
15. Shcheglovitova O.N., Parshina O.V., Guseva T.S., Maksyanina E.V., Ershov F.I. Voprosy virusologii — Virology Issues 2001; 6: 36–38.
16. Nekrasov A.V., Puchkova A.S., Ivanova A.S. Khimicheskie aspekty sozdaniya polioksidoniya. Immunologiya — Immunology 2000; 5: 19–23.
17. Tolkacheva N.I. Osobennosti vzaimosvyazi faktorov mestnogo immuniteta (lizotsim, immunoglobuliny) v sisteme pishchevareniya u detey. Dis. … kand. biol. nauk [The characteristics of relationship of local immunity factors (lysozyme, immunoglobulins) in digestive system in children. Abstract of Dissertation for the degree of Candidate of Biological Science]. Moscow; 1987.
18. Nikkels A.F., Pierard G.E. Approche factuelle du traitement de l’herpes genital. Factual approach to the treatment of genital herpes. Rev Med Liege 2000 May; 55(5): 430–437.
19. Pithon M.M., Andrede A.C. Primary herpetic gingivostomatitis in an adult patient using an orthodontic Appliance. Int J Odontostomat 2010; 4(2): 157–160.
20. Van Benthem B.H., Spaargaren J., Van Den-Hoek J.A., Merks J., Coutmho R.A., Prins M. Prevalence and risk factors of HSV-1 and HSV-2 antibodies in European HIV infected women. Sex Transm Infect 2001 Apr; 77(2): 20–124.
21. Slomka M.J. Client diagnostic techniques in genital herpes: their role in controlling the epidemic. Clin Lab 2000; 46(11–12): 591–607.
22. Isakov V.A., Arkhipova E.I., Isakov D.V. Gerpesvirusnye infektsii cheloveka: rukovodstvo dlya vrachey [Herpesvirus human infections: doctor’s manual] Saint-Petersburg: SpetsLit; 2006; 303 p.
23. Cusini M., Ghislanzoni M. The importance of diagnosing genital herpes. J Antimicrob-chemother 2001 Feb; 47: 9–16.
24. Kuzovkova T.V. Kliniko-immunologicheskaya kharakteristika bol’nykh genital’nym gerpesom (klinicheskoy i subklinicheskoy formami), voprosy terapii, profilaktiki retsidivov. Avtoref. dis. … kand. med. nauk [Clinicoimmunological characteristics of patients with genital herpes (clinical and subclinical forms), therapy problems, recurrences prophylaxis. Abstract of Dissertation for the degree of Candidate of Medical Science]. Yekaterinburg; 2000.
25. Khaldina M.V. Gerpes-assotsiirovannaya mnogoformnaya eritema. Klinika. Immunologiya. Diagnostika. Terapiya. Avtoref. dis. … kand. med. nauk [Herpes-associated multiform erythema. Clinical picture. Immunology. Diagnostics. Therapy. Abstract of Dissertation for the degree of Candidate of Medical Science]. Moscow; 2004.
26. Paludan S.R., Malmgaard L., Ellermann-Eriksen S., Boscty L., Mogensen S.C. Interferon (IFN)-gamma and Herpes simplex virus/tumor necrosis factor-alpha synergistically induce nitric oxide synthase 2 in macrophages through cooperative action of nuclear factor-kappa В and IFN regulator factor-1. Eur Cytokine Netw 2000; 12(2): 297–308.
27. Mezentseva M.V., Narovlyanskiy A.N., Ospel’nikova T.P., Ershov F.I. Voprosy virusologii — Virology Issues 2002; 1: 44–47.
28. Paludan S.R., Eliermann-Eriksen S., Malmgaard L., Mogen­sen S.C. Herpes simplex virus type 2 infection of macrophages impairs IL-4-mediated inhibition of NO production through TNF-alpha-induced activation of NF-kappaB. Arch Virol 2000; 145(3): 575–591.
29. Snimshchikova I.A., Yudina S.M., Medvedev A.I. Meditsinskaya immunologiya — Medical Immunology 2003; 3(3–4).
30. Novitskiy V.V., Ryazantseva N.V., Zhukova O.B. Byulleten’ sibirskoy meditsiny — Bulletin of Siberian medicine 2006; 2: 23–30.
31. Morrison L.A., Zhu L., Thebeau L.G. Vaccine-induced serum immunoglobin contrib­utes to protection from herpes simplex virus type 2 genital infection in the presence of immune T cells. J Virol 2001; 75(3): 1195–1204.
32. Tareeva T.G., Malinovskaya V.V., Shuginin I.O. et al. Rossiyskiy vestnik akushera-ginekologa — Russian Reporter of Obstetrician-Gynecologist 2004; 4(5): 82.
33. Gallais J., Boisnault P., Morel F., Clerc P., Letrillard L., Hebbrecht G. Herpes labialis et genital en medicine genrale. Herpes labialis and genitalis in general medicine. Ann Dermatol Venereol 2000 Jun–Jul; 127; 6–7: 596–602.
34. Khaldin A.A. Immunologicheskoe obosnovanie differentsirovannykh podkhodov k terapii prostogo gerpesa. Dis. … dokt. med. nauk [Immunological ground of differentiated approaches to herpes simplex therapy. Abstract of Dissertation for the degree of Candidate of Medical Science]. Moscow; 2001.
35. Shakov I.M. Vestnik poslediplomnogo meditsinskogo obrazovaniya — Medical postgraduate education reporter. Spets. vyp. Psikhoterapiya na rubezhe tysyacheletiy: opyt proshlogo — vzglyad v budushchee — Special issue. Psychotherapy at the turn of millennium: past experience and looking into the future 2000; 2: 20–21.
36. Riffault S., Carrat C., Milon G., Charley B., Colle J.H. Transient IFN-gamma synthesis in the lymph node draining a dermal site loaded with UV-irradiated herpes simplex virus type 1: an NFC- and CD3-dependent process regulated by IL-12 but not by IFN-alpha/beta. J Gen Virol 2000; 81; 10: 2365–2373.
37. Slomka M.J. Client diagnostic techniques in genital herpes: their role in controlling the epidemic. Clin Lab 2000; 46; 11–12: 591–607.
38. Rahman M., Alam A., Nessa K., Hossain A., Nahar S., Datta D., Alam-Khan S., Amin-Mian R., Albert M.J. Etiology sexually transmitted infections among street-based female sex workers in Dhaka, Bangladesh. J Clin Microbiol 2000 Mar; 38(3): 1244–1246.
39. Mayer L. Mucosal immunity and gastrointestinal antigen processing. J Pediatr Gastro-enterol Nutr 2000; 30: 4–12.
40. McKenna D.B., Neill W.A., Norval M. Herpes simplex virus-specific immune responses in subject with frequent and infrequent orofacial recrudescences. Br J Dermatol 2001 Mar; 144(3): 459–464.
41. Samgin M.A., Khaldin A.A. Prostoy gerpes (dermatologicheskie aspekty) [Herpes simplex (dermatological aspects)]. Moscow: MEDpress-inform; 2002; 160 p.

Spiridonova S.A., Tolmacheva S.M., Lukinykh L.M. Chronic Recurrent Herpetic Stomatitis as Immune System Disease. Sovremennye tehnologii v medicine 2012; (3): 121