Determination of Optimal Ozone Doses on the Basis of the Assessment of Hemostasis System Parameters in Burned Patients

The aim of the investigation was to assess the effect of clinical ozone doses on blood coagulation in the treatment of burned patients.

Materials and Methods. The control group had 34 of apparently healthy people. The comparison group consisted of patients receiving standard infusion-transfusion therapy used in clinic unit of thermal injuries (n=58). The study groups included the patients with burn disease, who underwent an ozone therapy course of five ozone procedures against the background of conventional treatment methods. They were injected a single dose of ozone intravenously in the form of ozonized saline solution: 40–80 µg (n=10), 120–160 µg (n=10), 200–250 µg (n=13), and 500 µg (n=16). The hemostatic system condition was studied by the following parameters: thrombin time, prothrombin time, activated partial thromboplastin time, fibrinogen concentration, antithrombin III activity.

Conclusion. The burned patients under the influence of ozone therapy and depending on ozone dose showed varying degrees of marked changes in the hemostatic system. The most optimal dosage affecting the blood coagulation system appeared to be the dose of 120–160 µg promoting the reduction of fibrinogen concentration and increased antithrombin III activity.

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Kostina О.V., Peretyagin S.P., Struchkov A.A. Determination of Optimal Ozone Doses on the Basis of the Assessment of Hemostasis System Parameters in Burned Patients. Sovremennye tehnologii v medicine 2013; 5(3): 79