Macular Pigment Optical Density Alteration as an Indicator of Diabetic Macular Edema Development
The aim of the investigation was to reveal the peculiarities of macular pigment optical density (MPOD) alteration in diabetic macular edema.
Materials and Methods. A total of 52 patients aged 55 to 71 years (mean, 63.0±5.2 years) were studied. The patients suffering from diabetes mellitus type 2 with diabetic macular edema (28 subjects, 30 eyes) were included in group 1 (main group). Group 2 (control group) included 24 patients (35 eyes) who did not suffer from any ophthalmic diseases and diabetes. All subjects underwent standard ophthalmic examination and fundus photographing followed with MPOD measurement using reflectometry method with non-mydreatic fundus camera VISUCAM 500® (Carl Zeiss Meditec AG, Germany).
Results. 78% of 28 patients from group 1 showed decline in all MPOD measurements as compared to control group. In particular, their mean MPOD was estimated as 0.10±0.01 standard units of optical density (р<0.05), while in the control group the same index was 0.25±0.01 standard units of optical density (р<0.05). The most significant MPOD reduction was observed in the projection of the retina edema area.
Conclusion. In diabetic macular edema, sharp decline in MPOD indices occurs. The correlation between quantitative MPOD indices and the size of the edema area has been revealed.
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