The Role of Stress-Protective Therapy in the Course of Chronic Cerebral Ischemia

The aim of the investigation is to determine clinical and pathogenetic value of stress-protective therapy in the course of experimental chronic cerebral ischemia.

Materials and Methods. In the remote period of the experimental cerebral ischemia, simulated by occlusion of the middle cerebral artery, the survival and parameters of the behavioral activity of Wistar rats, the state of oxidative processes, indices of blood cell reactivity, and morphological brain tissue changes have been assessed.

Results. After simulation of chronic cerebral ischemia in the experimental animals impairment of homeostatic parameters regulation preserved for 60 days, manifesting themselves by alteration of behavioral and laboratory indices without marked movement disorders. Reduction of adaptive and compensatory process activity in animals in chronic cerebral ischemia resulted in the decrease of their survival in the observation period by 56%. A combination of basic therapy with metabolic-type preparations provided 75% survival rate when antioxidants were used, and 100% survival when stress-limiting preparations were given. Inclusion of stress-limiting preparations in the therapeutic complex intensifies neuroprotective effect of the basic therapy and causes neurotrophic effect, maintaining cellular composition of the brain during chronic cerebral ischemia.

Conclusion. Neuroprotective effect of the stress-limiting preparation, given in the period of chronic cerebral ischemia, proves the hypothesis on the role of stress reaction in the pathogenesis of this disease. Findings of the experimental investigation confirmed the usefulness of including antistress preparations to the therapeutic complex in managing chronic cerebral ischemia.

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Antipenko E.A., Maksimova M.Y., Soldatov P.A. The Role of Stress-Protective Therapy in the Course of Chronic Cerebral Ischemia. Sovremennye tehnologii v medicine 2015; 7(3): 95, https://doi.org/10.17691/stm2015.7.3.14