Guided Osteogenesis Using Titanium Nickelide Mesh Constructs Implanted into a Bone Cavitary Defect
The aim of the investigation was to study the morphological characteristics of reparative osteogenesis using titanium nickelide mesh constructs implanted into a cavitary defect of the rat femoral metaphysis.
Materials and Methods. Reparative bone formation after implantation of titanium nickelide mesh structures into a cavitary defect of femoral metaphysis has been studied experimentally on rats. The following methods were used in the work: radiography, light and scanning electron microscopy, electron probe X-ray microanalysis.
Results. The implant microporous surface has been established to provide osteoblast adhesion, as well as osseointegration and adsorption of endogenic bone morphogenetic proteins. The implant possesses osteoconductive and osteoinductive characteristics, stops inflammatory processes. The membrane protective barrier, which prevents connective tissue ingrowth and provides guided osteogenesis, has formed around the implant in the defect periosteal zone. The defect is replaced with cancellous bone, the volumetric density of which is 1.5 times more than the control values.
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