Неинвазивный скрининг злокачественных новообразований полости рта in vivo с применением метода лазерно-индуцированной флюоресценции

В ходе исследования у 380 добровольцев зарегистрировано in vivo около 4000 спектров флюоресценции с участков ротовой полости в нормальном (n=133), потенциально злокачественном (n=155) и злокачественном (n=92) состоянии при возбуждении непрерывным волоконным He-Cd лазерой с длиной волны 325 нм. Анализ показал, что суммарные спектры из 7–8 полос возникают в различных видах молекул. В здоровом состоянии (у лиц без патологий полости рта, в том числе связанных с потреблением табачных изделий) слизистые оболочки щек, нижней губы и нижней поверхности языка имеют очень похожие спектры, в то время как спинка языка, его боковая поверхность и небо дают отличные от них и друг от друга спектры. При потенциально злокачественных и злокачественных заболеваниях спектры заметно отличаются на различных участках при различных состояниях. В связи с этим при оптической диагностике целесообразно использовать отдельные эталонные наборы данных о нормальных, потенциально злокачественных или злокачественных состояниях для различных участков.

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