Альтернативный метод контрастирования в оптической когерентной томографии: оценка синхронности мигания спеклов

В данной работе предлагается к рассмотрению альтернативный метод контрастирования в оптической когерентной томографии (ОКТ), основанный на оценке синхронности мигания спеклов структурных ОКТ B-сканов. Показано, что изменения в степени синхронизации мигания спеклов во времени могут быть использованы для выделения различных типов тканей, представляя таким образом новое эффективное контрастирование в ОКТ-визуализации.

Разработанная методика проверена на рассеивающих потоковых фантомах и in vivo на раковой опухоли шейки матки, выращенной в смоделированном отверстии дорсальной поверхности кожи мыши. Проведено показательное сравнение полученных значений степени синхронизации спеклов с результатами анализа автокорреляционной функции для демонстрации ее отличий. Фантомные и доклинические результаты in vivo показывают, что предлагаемый синхронизационный подход чувствителен к типу ткани/патологии и позволяет осуществлять количественную оценку опухоли и ее выделение на фоне окружающих здоровых тканей.

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