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Перспективы использования бактериоцинов нормальной микробиоты в антибактериальной терапии (обзор)

Перспективы использования бактериоцинов нормальной микробиоты в антибактериальной терапии (обзор)

М.И. Заславская, Т.В. Махрова, Н.А. Александрова, Н.И. Игнатова, И.В. Белова, А.Г. Точилина, И.В. Соловьева
Ключевые слова: бактериоцины; антимикробная терапия; нормальная микробиота человека.
2019, том 11, номер 3, стр. 136.
DOI: https://doi.org/10.17691/stm2019.11.3.17

Полный текст статьи

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Прогрессирующая резистентность микроорганизмов к антибиотикам стимулирует поиск альтернативной антимикробной терапии. В обзоре изучается возможность использования бактериоцинов в качестве антибактериальных препаратов. Дается определение бактериоцинов и объясняется их отличие от «классических» антибиотиков. Представлена современная классификация бактериоцинов, их свойства и механизмы действия. Приводятся примеры бактерий — представителей нормальной микробиоты человека — основных продуцентов бактериоцинов. Исследуется роль бактериоцинов микробиоты в обеспечении резистентности слизистых оболочек и стабилизации микробиома человека, а также возможность их применения при создании пробиотических препаратов. Описываются преимущества и недостатки бактериоцинов в качестве альтернативных антибактериальных препаратов. Рассматриваются варианты применения бактериоцинов в антимикробной терапии, а также способы их промышленного получения.

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