Laser Hyperthermia of Tumors with Nanothermosensibilizers
Aim of work is investigation of the gold nanoparticle use possibility for a local laser hyperthermia of tumor.
Materials and Methods. The investigation is made on 16 female-mice of the CBA line with a twisted cancer of the neck of the uterus. A solution of gold nanoparticles with a 0.2 ml volume with a concentration of 109 particles/ml was intravenously infused into the animals. The particle size was 200—250 nm; a maximum of extinction, connected with a plasma resonance, was at the wavelength of 850—950 nm. An observation of the nanoparticle penetration to a tumoral node was accomplished by a method of optical coherent tomography. A hyperthermia at the LSD-AZOR laser apparatus, generating radiation in a continuous mode at a wavelength of 810 nm, has been conducted in a period of the nanoparticle maximum accumulation in a tumor. The duration of effect to a tumor was 20 min. The antitumoral result of effect was assessed according to the tumor growth inhibition.
Results. A detection of a moment of the nanoparticle maximum concentration in a tumoral tissue achievement has permitted a more effective laser effect. The nanoparticle use as a thermosensibilizer has permitted to decrease a laser radiation power and provide a local effect.
