Issue 1 (2010)

The results of experimental and clinical investigations on the ozonotherapy biological effect study are summarized. The modern methods of ozonotherapy, well-known indications of the given oxidative therapy method are described. The basic fundamental ideas of the free radical role in physiologic and pathophysiologic conditions, reflected in works of the free-radical biology founders, are analyzed. A critical analysis of data, received at a use of ozonotherapy in oncology, is made. It is asserted, that a stimulation of the tumoral cell proliferation and a tumoral and toxic effect of the oxygen active forms are defined, first, by ozone concentration, second, a growth stage (initial level of a free-radical activity) both of tumor and the organism-carrier of tumor. The problems of ozonotherapy are analyzed and proposals are made on perspectives of the ozone technology development in biomedicine.