New Method of Prognosis, Diagnosis and Control of the Chronic Placental Insufficiency Therapy Effeciveness
Aim of investigation is establishment of the lipid peroxidation (LPO) and antioxidant protection system (AOPS) of blood value use possibility for assessment of the chronic placental insufficiency (ChPI) development risk, a degree of its gravity and a control of the conducted treatment.
Materials and Methods. 140 females in the pregnancy dates of 24 to 36 weeks, undergoing a study of the LPO and AOPS of blood, are examined. 400 pregnant females with a compensated form of ChPI, at a treatment of which the ozonotherapy (OT), hyperbarotherapy (HBTh) and traditional medicamental methods were used, are also examined.
Investigation results. The LPO and AOPS of blood values in a group of pregnant females with a high risk of a ChPI development already differed from the normal ones. The alterations in females with a compensated ChPI appeared to be more expressed, the investigating values in pregnant females with a subcompensated pathology differed more from the normal ones.
A dynamic observation has demonstrated that the ozonotherapy leads to normalization of the LPO-AOPS system state in pregnant females with a compensated ChPI. A HBTh and traditional treatment were less effective. Thus, the processes of free-radical oxidation and a state of AOPS in pregnant females can serve both for prognosia of a ChPI development and an assessment of a pathologic state gravity degree, a control of the conducted therapy effectiveness.
