New Method of the Liver Tumor Thermal Destruction with a Local Effect of the SHF Energy
Aim of investigation is elaboration of the liver tumor contact destruction method with the SHF energy, creation of a device for its realization and assessment of its work effectiveness in experiment.
Materials and Methods. The results of mathematical simulation and bench tests were used at elaboration and design of a device. The experiments on large laboratory animals with a following investigation of the effect zone with the light and electronic microscopy methods were accomplished for assessment of the device work effectiveness and its calibration.
Results. Three zones are formed in an hour in the liver tissue after a local SHF-effect: a zone of coagulating necrosis (a full destruction), a border zone (hemorrhages, vascular disorders, the hepatocyte necrosis) and the most distal one — a peripheral zone. The irreversible changes, testifying to the thermal and ischemically-hypoxic lesions of hepatocytes, are observed in a zone of necrosis and a border zone. The liver tissue in a peripheral zone at a light microscopy looks like an intact one, and the myelinolike structures, testifying to the hepatocyte cytolemma adaptation failure to the increasing edema and inevitable death of the cells, are detected in a half of hepatocytes at the electronic and microscopic investigation. The heterogeneity of the peripheral zone hepatocyte lesion requires a following study of a process dynamics.
Conclusion. A method of local hyperthermia with the SHF-effect energy has demonstrated a high effectiveness of the destruction area form and size programming at a brief effect.
