Experimental Investigation of the Ferrum (III) Hydroxide Polymaltosate Preparation Influence Peculiarities on the Lipid Peroxidation Values

Aim of investigation is a study of the ferrum (III) hydroxide polymaltosate preparation influence peculiarities on the lipid peroxidation and antioxidant protection values in blood of experimental animals at the background of a ferrodeficient anemia.

Materials and Methods. The experiment is made on 120 nonlinear male-rats. The values of induced biochemiluminescence, a content of malone dialdehyde, an activity of superoxidedismutase and catalase, a concentration of ceruloplasmin in blood of experimental animals at infusion of a preparation, containing a trivalent ferrum, — a ferrum (III) hydroxide polymaltosate (maltofer) — in equitherapeutic dose of 17.14 mg/kg a day (calculating the elementary ferrum) have been detected during investigation for 30 days.

Results. A trivalent ferrum (III) hydroxide polymaltosate preparation (maltofer) stipulates at the early stages an insignificant, and at the later stages — expressed influence on the pointed process, which is confirmed by an increase of a free-radical oxidation process abatement rate in blood plasma of experimental animals, and also a decrease of a superoxidedismutase activity (in a day of its infusion), a decrease of a malone dialdehyde concentration (in 5 days), a decrease of the antioxidant and superoxidedismutase activity (in 10 days), an increase of a plasma free-radical activity and a free-radical oxidation process abatement rate (in 20 days), a decrease of a malone dialdehyde content (in 30 days).

Conclusion. The investigating trivalent ferrum preparation activates a process of lipid peroxidation. Its distinctive feature is a more expressed influence on the pointed process at the late stages of its infusion.

Lovtsova L.V., Kuzin V.B. Experimental Investigation of the Ferrum (III) Hydroxide Polymaltosate Preparation Influence Peculiarities on the Lipid Peroxidation Values. Sovremennye tehnologii v medicine 2010; (3): 35