Drug Sensitivity of Nonspecific Lung Pathology Agents in Experimental Conditions of Tobacco Smoke Condensate Exposure
The aim of the investigation is to study the effect of tobacco smoke products on drug sensitivity of typical bacterial agents of nonspecific lung pathology: Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella pneumoniaе.
Materials and Methods. There have been performed 786 studies to determine drug sensitivity to antibacterial agents (ABA) after the subcultures being cultured on media with tobacco smoke condensate. From 7 to 9 of various ABA have been tested using a disco-diffusion technique.
Results. There was observed the decrease of the diameter of zones of growth retardation near the discs with the following antibiotics: erythromycin, levofloxacin, oxacillin (S. pneumoniaе); cefotaxime (р<0,05), levomycetin (Н. influenzae); cefepime (р<0,05), amoksiklav, meropenem, cefotaxime (K. pneumoniaе). It gives evidence of the possibility to form drug sensitivity to ABA in response to tobacco smoke products.
