The Assessment of Dynamics of Free Radical Processes in Cerebral Tumour Tissue and Brain Metastases of Various Localizations
The aim of the investigation is to study the dynamics of some activity indexes of lipid peroxidation in the tissue of primary cerebral tumours and brain metastases tumours for the purpose of treatment optimization.
Materials and Methods. There have been studied tumour tissue samples (anaplastic gliomas and benign astrocytomas) and their perifocal areas taken from the patients during the oncotomy operations and the surgeries on brain metastases tissues excision (breast cancer, lung cancer, renal cell carcinoma, skin melanoma).
Results. Primary malignancies and brain cancer metastases of various localization have been stated to have common biochemical mechanisms. There has been noticed the more aggressive “metabolic” nature of brain cancer metastases of various localization compared to malignant gliomas. The metastases near hypothalamus as well as multiple metastases have been revealed to be of more aggressive nature.
