The Effectiveness of Tachocomb Use in Hepatobiliary Surgery
The aim of the study is to assess the hemostatic possibilities of TachoComb biopolymer in operations on the liver and biliary tructs.
Materials and Methods. The following preparations were used in the study: hemostatic collagen sponge, Tabotamp, Gelaspon, Trombin, TachoComb. An acute experiment on animals was performed and as a result there was revealed a priority effect of TachoComb in the arrest of parenchymatous bleeding from liver tissue. Morphological characteristics of TachoComb effect on liver wounds were studied in a chronic experiment.
Results. Experiments proved that the preparation does not cause an acute inflammation and a local toxic reaction in tissues. The biopolymer initiates an early fibroblastic reaction and angiogenesis. Mesothelial membranes is restored on preparation surface on the 7—14th day. Biodegradation of TachoComb starts after 30 days the preparation has been applied on liver wounds. Preparation applying techniques in open and laparoscopic operations are suggested. Hemostatic effectiveness of TachoComb is indicated for clinical use.
