The Change of Infrared Spectrum Parameters of Biological Tissues of Animals-carriers of Tumours Against the Background of Combined Administration of Doxorubicin and Ozone

The aim of the study is the search of correlation dependence of infrared (IR) parameters of biological tissues of animals-carriers of tumours on concentration changes of some phosphorus-containing metabolites against the background of complex administration of ozone and doxorubicin (DR).

Materials and Methods. Experimental animals, white non-pedigree female rats (n=45), with tumour strain BC-1 (breast cancer) were administered intraperitoneal introduction of ozonized physiological saline (OPS) (ozone dose: 20 mg per an animal, 6 procedures every other day) interchanging it with DR administration (dosage: 0.04 mg per an animal, 5 procedures every other day). The animals were involved into the experiment on the 45th day after tumour subinoculation.

The research was carried out using the technique of IR-spectroscopy of biological tissues.

Conclusion. The administration of OPS, DR and OPS+DR complex to the animals with tumour strain BC-1 changes the parameters of IR spectra of the liver, kidneys, lungs, brain, tumour of these animals. OPS+DR complex has higher therapeutic effect compared to monochemotherapy. Therefore, ozone can be considered as a chemical agent modifying the cellular element action and enhancing tumour cells damage that emphasizes the feasibility of chemotherapy performed in combination with ozone therapy.

Krasnikova О.V., Gordetsov А.S., Kontorstchikova K.N., Krylov V.N., Sazanov А.I. The Change of Infrared Spectrum Parameters of Biological Tissues of Animals-carriers of Tumours Against the Background of Combined Administration of Doxorubicin and Ozone. Sovremennye tehnologii v medicine 2011; (3): 83