The Dynamics of Lipid Peroxidation Indexes in Blood Serum in Response to 3-oxypyridine Derivatives in Induced and Transplantable Neoplasms
The objective of the work is to study the effect of 3-oxypyridine derivatives (Mexidol and Emoxipinum) on lipid peroxidation processes in rats with transplantable Lewis’s carcinoma of lung and in urethane induced carcinogenesis.
Materials and Methods. Two groups of white non-pedigree rats (n=30) were induced tumour growth by urethane within 28 weeks, and Lewis’s carcinoma of lung was transplanted to the rats in other two groups. Mexidol and Emoxipinum were used to correct carcinogenic effect. Lipid peroxidation indexes were studied in all the groups.
Conclusion. Mexidol and Emoxipinum in the doses studied limit the increase of lipid peroxidation products in tumour process in animals, both in urethane induced lung cancers and in transplantable Lewis’s carcinoma of lung, as well as have a modeling effect on catalase activity in blood serum.
