Modern Methods of Infusion Therapy in Patients with Shock

The aim of the investigation is the assessment of the effect of various variant of infusion therapy on the function of organs and systems of patients with hemorrhagic and traumatic shock.

Materials and Methods. There have been presented the results of the single-blind prospective cohort randomized study (by envelope technique) of 219 patients with hemorrhagic and traumatic shock divided into group depending on infusion therapy variant.

Results. The use of 6% hydroxyethylated starch colloid solution 200/0.5 in infusion therapy program in patients with II–III degree hemorrhagic and traumatic shock was stated not to contribute to effective correction of hypovolemia and systemic hemodynamicss as well as have the negative effect on hemostasis that causes the severity of multiple organ failure. Meanwhile, the use of 4% oxypolygelatin in these patients appeared to correct systemic hemodynamics and not to contribute to severe organ dysfunctions. The use of balanced crystalloid solution of sterofundin isotonic in contrast to imbalanced solution of normal saline has a positive effect on electrolyte and acid-base composition of blood plasma in infusion therapy of patients with II–III degree hemorrhagic and traumatic shock.

1. Molchanov I.V., Bulanov A.Yu., Shulutko E.M. Klin Anesteziol i Reanimatol — Clinical Anesthesiology and Critical Care Medicine 2004; 3: 19–22.
2. Zander R., Adams H.A., Boldt J. et al. Anesthesiol Intensiv Notfall Schmerzen — Clinical Anesthesiology and Critical Care Medicine 2005; 40: 321–326.
3. Wiedermann С.J. Hydroxyethyl starch — can the safety problems be ignored? Wien Klin Wochenshr — Wien Klin Wochenshr (Vienna Clinical Weekly Reporter) 2004; 116(17–18): 583–594.
4. Stukanov M.M., Lukach V.N., Girsh A.O. et al. Meditsina katastrof — Emergency Medicine 2010; 1(69): 13–16.
5. Baryshev B.A. Krovezameniteli i komponenty krovi [Blood substitutes and components]. Saint Petersburg; 2005; 158 p.
6. Barkagan Z.S., Momot A.P. Osnovy diagnostiki narusheniy gemostaza [Principles of hemostasis disorders diagnostics]. Moscow: Meditsina; 1999; 129 p.
7. Rebrova O.Yu. Statisticheskiy analiz meditsinskikh dannykh: primenenie paketa prikladnykh programm STATISTICA [Statistical analysis of medical data. STATISTICA application program package]. Moscow; 2002; 305 p.
8. Lukach V.N., Stukanov M.M., Girsh A.O. et al. Omskiy nauchnyy vestnik — Omsk Scientific Reporter 2010; 1(94): 73–77.
9. Stukanov M.M., Lukach V.N., Girsh A.O. et al. Vestnik Ural’skoy meditsinskoy akademicheskoy nauki — Herald of Ural Medical Academic Science 2011; 2(34): 26–30.
10. Stukanov M.M., Lukach V.N., Girsh A.O. et al. Anesteziologiya i reanimatologiya — Anesthesiology and Critical Care Medicine 2011; 2: 27–30.
11. Stukanov M.M., Lukach V.N., Girsh A.O. et al. Khirurgiya. Zhurnal im. N.I. Pirogova — Surgery. Journal named after N.I. Pirogov 2011; 5: 51–55.
12. Girsh A.O., Lukach V.N., Stukanov M.M. et al. Meditsina katastrof — Emergency Medicine 2009; 4(68): 19–22.
13. Lukach V.N., Stukanov M.M., Girsh A.O. et al. Vestn Hir im II Grekova — Surgery Reporter named after I.I. Grekov 2009; 6(168): 62–66.
14. Lang W., Zander R. Prediction of dilutional acidosis based on the revised classical dilution concept for bicarbonate. J Appl Physiol 2005; 98: 62–71.

Girsh А.О., Stukanov М.М., Yudakova Т.N., Mamontov V.V., Maksimishin S.V. Modern Methods of Infusion Therapy in Patients with Shock. Sovremennye tehnologii v medicine 2012; (3): 73