The Study of Combined Effect of Microwave Energy and Gold Nanoparticles on Tumor in Experiment

The aim of the investigation is to study the characteristics of the effect of microwave energy on tumors in the presence of gold nanoparticles.

Materials and Methods. The research was carried out on experimental tumor model cervical cancer. In the experiment there were used gold nanoparticles in the form of rods, 60×30 nm in size. Nanoparticles were injected to animals (mice) intravenously, 150 mg/kg. There was compared the efficiency of the following pulse sequences: 50 J (three times) and 150 J (once). The criteria of efficiency were the percent of tumor growth inhibition, and the increase of lifespan, as well as structural changes of tumor tissue revealed by optical microscopy.

Results. The highest anti-tumor activity was demonstrated by three times sequence of microwave energy of 50 J, just as with, so without gold nanoparticles. The effect of microwave freguency of low capacity could contribute to both significant changes of tumor structure, and tumor growth inhibition and the increase of lifespan of the animals. Gold nanoparticles in microwave therapy were shown to have no marked contribution to anti-tumor effect.

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Sirotkina М.А., Еlagin V.V., Makarova А.А., Snopova L.B., Prodanets N.N., Strikovsky А.V., Galka А.G., Kostrov А.V., Zagaynova Е.V. The Study of Combined Effect of Microwave Energy and Gold Nanoparticles on Tumor in Experiment. Sovremennye tehnologii v medicine 2012; (4): 30