New Aspects of Correlation of Free Radical Oxidation and the Severity of Pathological Process in Congenital Dislocated Hip and Degenerative Dystrophic Diseases of Hip Joint in Children

The aim of the investigation is to prove the correlation of free radical processes and the state of anti-oxidant system, and the severity of pathological process in children with congenital dislocated hip.

Materials and Methods. There were examined 143 patients with congenital dislocated hip aged from 4 to 17 years, they were divided into three groups: the 1st group (n=39) — children with noncomplicated disease, the 2nd group (n=47) — children with coxarthrosis, the 3rd group (n=32) — children with Legg’s disease. The control group (n=161) included virtually healthy children. The investigations of free radical production level and the condition of anti-oxidant system were carried out in patients’ blood serum, plasma, and erythrocytes.

Results. There was revealed statistically significant correlation between the intensity of lipid peroxidation and the degree of manifestation of dystrophic changes in an affected joint. There was registered the activation of anti-oxidant protection systems in children suffering from hip joint pathology due to the necessity of limitation of free radical processes intensity and their maintenance at an adequate level.

Conclusion. The indices of lipid peroxidation intensity and anti-oxidant enzymes activity as diagnostic criteria enable to estimate the depth of pathological changes in children with congenital dislocated hip and degenerative and dystrophic diseases of hip joints, and timely perform effective therapeutic interventions to prevent the deformity of femoral head.

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Strelkova I.G., Musikhina I.V., Bogosian А.B., Sidorkin V.G., Starikova М.А., Sidorkina А.N., Kusnetsova V.L. New Aspects of Correlation of Free Radical Oxidation and the Severity of Pathological Process in Congenital Dislocated Hip and Degenerative Dystrophic Diseases of Hip Joint in Children. Sovremennye tehnologii v medicine 2012; (4): 73