The Potential and Limitations of Intravascular Optical Coherence Tomography

There has been analyzed the experience gained on optical coherence tomography (OCT) application for diagnosis and control of arterial sclerotic disease. The principles of OCT-images acquisition have been described; there have been assessed the advantages and disadvantages of intravascular OCT devices used in clinical practice; and safety and the capabilities of intravascular OCT-procedure have been discussed. Great potential of intravascular OCT for understanding and management of arterial sclerotic disease has been demonstrated. There have been considered the possibilities of life-time diagnostics of a “vulnerable” atherosclerosis plaque, the determination of calcium and macrophages content in atherosclerosis plaque, as well as the features of coronarothrombosis. There has been brought to a sharper focus the role of intravascular OCT in stenting monitoring. The ways of improvement of intravascular OCT and its further development prospects have been presented.

1. Rukovodstvo po opticheskoy kogerentnoy tomografii [Handbook of optical coherence tomography]. Pod red. Gladkovoy N.D., Shakhovoy N.M., Sergeeva A.M. [N.D. Gladkova, N.M. Shakhova, A.M. Sergeev (editors)]. Moscow: Fizmatlit; 2007; 296 p.
2. Rollins A.M., Ung-arunyawee R., Chak A., Wong R.C.K., Kobayashi K., Sivak M.V., Izatt J.A. Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design. Opt Lett 1999; 24 (19): 1358–1360.
3. Tearney G.J., Boppart S.A., Bouma B.E., Brezinski M.E., Weissman N. J., Southern J.F., Fujimoto J.G. Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography: erratum. Opt Lett 1996; 21(12): 912.
4. Tearney G.J., Brezinski M.E., Bouma B.E., Boppart S.A., Pitris C., Southern J.F., et al. In vivo endoscopic optical biopsy with optical coherence tomography. Science 1997; 276: 2037–2039.
5. Xi J., Huo L., Wu Y., Cobb M.J., Hwang J.H., Li X. High-resolution OCT balloon imaging catheter with astigmatism correction. Opt Lett 2009; 34(13): 1943–1945.
6. Yun S.H., Tearney G.J., Vakoc B.J., Shishkov M., Yelin R., Oh W.Y., et al. Comprehensive volumetric optical microscopy in vivo. Nat Med 2006; 12: 1429–1433.
7. Sergeev A.M., Gelikonov V.M., Gelikonov G.V., Feldchtein F.I., Kuranov R.V., Gladkova N.D., et al. In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa. Optics Express 1997; 1(13): 432–440.
8. Jäckle S., Gladkova N., Feldchtein F., Terentieva A., Brand B., Gelikonov G., Gelikonov V., Sergeev A., Fritscher-Ravens A., Freund J., Seitz U., Soehendra S., Schrödern N. In vivo endoscopic optical coherence tomography of the human gastrointestinal tract-toward optical biopsy. Endoscopy 2000; 32(10): 743–749.
9. Huang D., Swanson E.A., Lin C.P., Schuman J.S., Stinson W.G., Chang W., et al. Optical coherence tomography. Science 1991; 254; 1178–1181.
10. http://www.assomedica.by.
11. Diaz-Sandoval L.J., Bouma B.E., Tearney G.J., Jang I.K. Optical coherence tomography as a tool for percutaneous coronary interventions. Catheter Cardiovasc Interv 2005; 65: 492–496.
12. Grube E., Gerckens U., Buellesfeld L., Fitzgerald P.J. Images in cardiovascular medicine. Intracoronary imaging with optical coherence tomography: a new high-resolution technology providing striking visualization in the coronary artery. Circulation 2002 Oct 29; 106(18): 2409–2410.
13. Jang I.K., Bouma B.E., Kang D.H., Park S.J., Park S.W., Seung K.B., et al. Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound. Journal of the American College of Cardiology 2002 Feb 20; 39(4): 604–609.
14. Jang I.K., Tearney G., Bouma B. Visualization of tissue prolapse between coronary stent struts by optical coherence tomography-comparison with intravascular ultrasound. Circulation 2001 Nov 27; 104(22): 2754.
15. Kume T., Akasaka T., Kawamoto T., Watanabe N., Toyota E., Sukmawan R., et al. Visualization of neointima formation by optical coherence tomography. Int Heart J 2005 Nov; 46 (6): 1133–1136.
16. Brezinski М., Saunders К., Jesser C., Li Х., Fujimoto J. Index matching tо improve ОСТ imaging through blood. Circulation 2001 April 17; 103(15): 1999–2003.
17. Jang I.K., Tearney G.J., MacNeill B.D., Takano M., Moselewski F., Iftima N., et al. In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography. Circulation 2005; 111: 1551–1555.
18. Yamaguchi T., Terashima M., Akasaka T., Hayashi T., Mizuno K., Muramatsu T., et al. Safety and feasibility of аn intravascular optical coherence tomography image wire system in the clinical setting. Аm J Cardiol 2008; 101: 562–567.
19. Prati F., Cera M., Ramazzotti V., Imola F., Giudice R., Albertucci M. Safety and feasibility of a new non-occlusive technique for facilitated intracoronary optical coherence tomography (OCT) acquisition in various clinical and anatomical scenarios. EuroIntervention 2007; 3: 365–370.
20. Herrero-Garibi J., Cruz-Gonzalez I., Parejo-Diaz P., Jangc I.-K. Optical coherence tomography: its value in intravascular diagnosis today. Rev Esp Cardiol 2010; 63(8): 951–962.
21. Rieber J., Meissner O., Babaryka G., Reim S., Oswald M., Koenig A., et al. Diagnostic accuracy of optical coherence tomography and intravascular ultrasound for the detection and characterization of atherosclerotic plaque composition in ex vivo coronary specimens: a comparison with histology. Coron Artery Dis 2006; 17: 425–430.
22. Brezinski М.Е., Теаrnеу G.J., Воumа В.Е., Izatt J.А., Нее М.R., Swanson E.A., et al. Optical соhеrеnсе tomography for optical biopsy: properties and demonstration of vascular pathology. Circulation 1996; 93: 1206–1213.
23. Yabushita H., Bouma B.E., Houser S.L., Aretz H.T., Jang I.K., Schlendorf K.H., et al. Characterization of human atherosclerosis by optical coherence tomography. Circulation 2002 Sep 24; 106(13): 1640–1245.
24. Tearney G.J., Yabushita H., Houser S.L., Aretz H.T., Jang I.K., Schlendorf K.H., et al. Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography. Circulation 2003; 107: 113–119.
25. Kume T., Akasaka T., Kawamoto T., Watanabe N., Toyota E., Neishi Y., et al. Assessment of coronary arterial plaque by optical coherence tomography. Am J Cardiol 2006 Feb; 97: 1172–1175.
26. Virmаni R., Kolodgie Р.D., Burke А.Р., Farb A., Schwartz S.M. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2000; 20: 1262–1275.
27. Virmani R., Burke А.Р., Farb А., Kolodgie Р.D. Pathology оf unstable plaque. Prog Cardiovasc Dis 2002; 44: 349–356.
28. Regar E., Schaar J., Serruys P.W. Images in cardiology. Acute recoil in sirolimus eluting stent: real time, in vivo assessment with optical coherence tomography. Heart 2006 Jan; 92(1): 123.
29. Suzuki Y., Ikeno F., Yeung A.C. Drug-eluting stent strut distribution: a comparison between Cypher and Taxus by optical coherence tomography. J Invasive Cardiol 2006; 18: 111–114.
30. Ito S., Itoh M., Suzuki T. Intracoronary imaging with optical coherence tomography after cutting balloon angioplasty for in-stent restenosis. J Invasive Cardiol 2005; 17: 369–370.
31. Matsumoto D., Shite J., Shinke T., et al. Neointimal coverage of sirolimus-eluting stents at 6-month follow-up: evaluated by optical coherence tomography. Eur Heart J 2007; 28: 961–967.
32. Farooq M.U., Khasnis A., Majid A., Kassab M.Y. The role of optical coherence tomography in vascular medicine. Vascular Medicine 2009; 14: 63–71.
33. Kubo T., Imanishi T., Takarada S., Kuroi A., Ueno S., Yamano T., et al. Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy. J Am Coll Cardiol 2007 Sep 4; 50(10): 933–939.
34. Kume T., Akasaka T., Kawamoto T., Okura H., Watanabe N., Toyota E., et al. Measurement of the thickness of the fibrous cap by optical coherence tomography. Am Heart J 2006; 152(755): 751–754.
35. Sawada T., Shite J., Garcia-Garcia H.М., Shinke T., Watanabe S., Otake H., et al. Feasibility of combined use of intravascular ultrasound radiofrequency data analysis and optical coherence tomography for detecting thin-cap fibroatheroma. European Heart Journal 2008 April 7; 29: 1136–1146.
36. Kubo T., Imanishi T., Takarada S., Kuroi A., Ueno S., Yamano T., et al. Implication of plaque color classification for assessing plaque vulnerability: a coronary angioscopy and optical coherence tomography investigation. JACC Cardiovasc Interv 2008; 1: 74–80.
37. Kashiwagi M., Tanaka A., Kitabata H., Tsujioka H., Kataiwa H., Komukai K., et al. Feasibility of noninvasive assessment of thin-cap fibroatheroma by multidetector computed tomography. JACC Cardiovasc Imaging 2009; 2: 1412–1419.
38. Fujii K., Masutani M., Okumura T., Kawasaki D., Akagami T., Ezumi A., et al. Frequency and predictor of coronary thin-cap fibroatheroma in patients with acute myocardial infarction and stable angina pectoris a 3-vessel optical coherence tomography study. J Am Coll Cardiol 2008; 52: 787–788.
39. Greenland P., Bonow R.O., Brundage B.H., Budoff M.J., Eisenberg M.J., Grundy S.M., et al. ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the american college of cardiology foundation clinical expert consensus task force (ACCF/AHA writing committee to update the 2000 expert consensus document on electron beam computed tomography) developed in collaboration with the society of atherosclerosis imaging and prevention and the society of cardiovascular computed tomography. J Am Coll Cardiol 2007; 49(3): 378–402.
40. Mintz G.S., Popma J., Pichard A.D., Kent K.M., Satler L.F., Chuang Y.C., et al. Patterns of calcification in coronary artery disease. A statistical analysis of intravascular ultrasound and coronary angiography in 1155 lesions. Circulation 1995; 91: 1959–1965.
41. Wexler L., Brundage B., Crouse J., Detrano R., Fuster V., Maddahi J., et al. Coronary artery calcification: pathophysiology, epidemiology, imaging methods, and clinical implications. A statement for health professionals from the american heart association. Writing group. Circulation 1996; 94: 1175–1192.
42. Agatston A.S., Janowitz W.R., Hildner F.J., Zusmer N.R., Viamonte M.J., Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990; 15: 827–832.
43. Carr J.J., Nelson J.C., Wong N.D., McNitt-Gray M., Arad Y., Jacobs J., et al. Calcified coronary artery plaque measurement with cardiac ct in population-based studies: standardized protocol of multi-ethnic study of atherosclerosis (mesa) and coronary artery risk development in young adults (cardia) study. Radiology 2005; 234: 35–43.
44. Callister T.Q., Cooil B., Raya S.P., Lippolis N.J., Russo D.J., Raggi P. Coronary artery disease: improved reproducibility of calcium scoring with an electron-beam ct volumetric method. Radiology 1998; 208: 807–814.
45. Mintz G.S., Pichard A.D., Kovach J.A., Kent K.M., Satler L.F., Javier S.P., et al. Impact of preintervention intravascular ultrasound imaging on transcatheter treatment strategies in coronary artery disease. Am J Cardiol 1994; 73: 423–430.
46. Moussa I., Di Mario C., Moses J., Reimers B., Di Francesco L., Martini G., et al. Coronary stenting after rotational atherectomy in calcified and complex lesions. Angiographic and clinical follow-up results. Circulation 1997; 96: 128–136.
47. Kubo T., Xu C., Wang Z., van Ditzhuijzen N.S., Bezerra H.G. Plaque and thrombus evaluation by optical coherence tomography. Int J Cardiovasc Imaging 2011; 27(2): 289–298.
48. Wang Z., Kyono H., Bezerra H.G., Wang H., Gargesha M., Alraies C., et al. Semi-automatic segmentation and quantification of calcified plaques in intracoronary optical coherence tomography images. J Biomed Opt 2010; 15: 061711.
49. Lusis A.J. Atherosclerosis. Nature 2000; 407: 233–241.
50. Moreno P.R., Falk E., Palacios I.F., Newell J.B., Fuster V., Fallon J.T. Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture. Circulation 1994; 90: 775–778.
51. MacNeill B.D., Bouma B.E., Yabushita H., Jang I.K., Tearney G.J. Intravascular optical coherence tomography: cellular imaging. J Nucl Cardiol 2005; 12: 460–465.
52. MacNeill B.D., Jang I.K., Bouma B.E., Iftimia N., Takano M., Yabushita H., et al. Focal and multi-focal plaque distributions in patients with macrophage acute and stable presentations of coronary artery disease. Journal of the American College of Cardiology 2004 Sep 1; 44(5): 972–979.
53. Drexler W., Morgner U., Kartner F.X., Pitris C., Boppart S.A., Li X.D., et al. In vivo ultrahighresolution optical coherence tomography. Opt Lett 1999; 24: 1221–1223.
54. Kume T., Akasaka T., Kawamoto T., Ogasawara Y., Watanabe N., Toyota E., et al. Assessment of coronary arterial thrombus by optical coherence tomography. Am J Cardiol 2006 Jun 15; 97(12): 1713–1717.
55. Mehanna E.A., Attizzani G.F., Kyono H., Hake M., Bezerra H.G. Assessment of coronary stent by optical coherence tomography, methodology and definitions. Int J Cardiovasc Imaging 2011; 27(2): 259–269.
56. Yao Z.H., Matsubara T., Inada T., Suzuki Y., Suzuki T. Neointimal coverage of sirolimus-eluting stents 6 months and 12 months after implantation: evaluation by optical coherence tomography. Chin Med J 2008; 121: 503–507.
57. Gonzalo N., Garcia-Garcia H.M., Serruys P.W., Commissaris K.H., Bezerra H., Gobbens P., Costa M., Regar E. Reproducibility of quantitative optical coherence tomography for stent analysis. EuroIntervention 2009; 5(2): 224–232.
58. Rosenthal N., Guagliumi G., Sirbu V. Comparison of intravascular ultrasound and optical coherence tomography for the evaluation of stent segment malapposition. J Am Coll Cardiol 2009; 53 (A1–A99 (supplement)).
59. Suzuki Y., Ikeno F., Koizumi T., Tio F., Yeung A.C., Yock P.G., Fitzgerald P.J., Fearon W.F. In vivo comparison between optical coherence tomography and intravascular ultrasound for detecting small degrees of in-stent neointima after stent implantation. JACC Cardiovasc Interv 2008; 1(2): 168–173.
60. Guagliumi G., Musumeci G., Sirbu V., Bezerra H.G., et al. Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents. JACC Cardiovasc Interv 2010; 3(5): 531–539.
61. Guagliumi G., Sirbu V., Bezerra H., Biondi-Zoccai G., Fiocca L., et al. Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical coherence tomography in acute myocardial infarction) study. JACC Cardiovasc Interv 2010; 3(6): 680–687.
62. Guagliumi G., Sirbu V., Musumeci G., Bezerra H.G., Aprile A., Kyono H., et al. Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: optical coherence tomography drug-eluting stent investigation (OCTDESI). Circ Cardiovasc Interv 2010; 3(4): 367–375.
63. Guagliumi G., Sirbu V. Optical coherence tomography: high resolution intravascular imaging to evaluate vascular healing after coronary stenting. Catheter Cardiovasc Interv 2008; 72(2): 237–247.
64. Takarada S., Imanishi T., Liu Y., Ikejima H., Tsujioka H., Kuroi A., Ishibashi K., et al. Advantage of next-generation frequency-domain optical coherence tomography compared with conventional time-domain system in the assessment of coronary lesion. Catheter Cardiovasc Interv 2010; 75(2): 202–206.
65. Capodanno D., Prati F., Pawlowsky T., Cera M., La M.A., Albertucci M., et al. Comparison of optical coherence tomography and intravascular ultrasound for the assessment of in-stent tissue coverage after stent implantation. EuroIntervention 2009; 5(5): 538–543.
66. Onuma Y., Serruys P.W., Perkins L.E., Okamura T., Gonzalo N., Garcia-Garcia H.M., et al. Intracoronary optical coherence tomography and histology at 1 month and 2, 3, and 4 years after implantation of everolimus-eluting bioresorbable vascular scaffolds in a porcine coronary artery model: an attempt to decipher the human optical coherence tomography images in the ABSORB trial. Circulation 2010; 122(22): 2288–2300.
67. Murata A., Wallace-Bradley D., Tellez A., Alviar C., Aboodi M., Sheehy A., Coleman L., Perkins L., et al. Accuracy of optical coherence tomography in the evaluation of neointimal coverage after stent implantation. JACC Cardiovasc Imaging 2010; 3(1): 76–84.
68. Bezerra H.G., Guagliumi G., Valescchi O., Lortkipanidze N., Rosenthal N., Tahara S., Kyono H., et al. Unraveling the lack of Neointimal hyperplasia detected by intravascular ultrasound using optical coherence tomography: lack of spatial resolution or a true biological effect? J Am Coll Cardiol 2009; 10(Suppl A): 90A.
69. Finn A.V., Joner M., Nakazawa G., et al. Pathological correlates of late drugeluting stent thrombosis: strut coverage as a marker of endothelialization. Circulation 2007; 115(18): 2435–2441.
70. Cook S., Wenaweser P., Togni M., Billinger M., et al. Incomplete stent apposition and very late stent thrombosis after drug-eluting stent implantation. Circulation 2007; 115(18): 2426–2434.
71. Caldera A.E., Cruz-Gonzalez I., Bezerra H.G., Cury R.C., Palacios I.F., Cockrill B.A., Inglessis-Azuaje I. Endovascular therapy for left main compression syndrome. Case report and literature review. Chest 2009; 135(6): 1648–1650.
72. Ishigami K., Uemura S., Morikawa Y., Soeda T., Okayama S., Nishida T., Takemoto Y., et al. Long-term follow-up of neointimal coverage of sirolimus-eluting stents: evaluation with optical coherence tomography. Circ J 2009; 73(12): 2300–2307.
73. Miyoshi N., Shite J., Shinke T., Otake H., Tanino Y., Ogasawara D., Sawada T., Kawamori H., et al. Comparison by optical coherence tomography of paclitaxel-eluting stents with sirolimuseluting stents implanted in one coronary artery in one procedure — 6-month follow-up. Circ J 2010; 74(5): 903–908.
74. Suzuki N., Guagliumi G., Bezerra H.G., Sirbu V., Rosenthal N., Musumeci G., Aprile A., Wang H., et al. The impact of an eccentric intravascular image wire during coronary optical coherence tomography imaging. EuroIntervention 2011; 6(8): 963–969.
75. Prati F., Regar E., Mintz G.S., Arbustini A., Di Mario C., Jang I.K., Akasaka T., Costa M., et al. Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis. Eur Heart J 2010; 31(4): 401–415.
76. Regar E., Serruys P.W., Van Leeuwen T.Ge. Optical coherence tomography in cardiovascular research. London: Informa Healthcare; 2007.
77. Prati F., Jenkins M.W., Giorgio A.D., Rollins A.M. Intracoronary optical coherence tomography, basic theory and image acquisition techniques. Int Journal of Cardiac Imaging 2011 Feb; 27(2): 251–258.
78. Giattina S.D., Courtney B.K., Herz P.R., Harman M., Shortkroff S., Stamper D.L., et al. Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT). Int J Cardiol 2006 Mar 8; 107(3): 400–409.
79. Nadkami S.K., Pierce M.C., Park B.H., de Boer J.F., Whittaker P., Bouma B.E., et al. Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography. Journal of the American College of Cardiology 2007; 49(13): 1474–1481.
80. Chen Z., Milner T.E., Srinivas S., Wang X., Malekafzali A., Gemert M.J.C., Nelson J.S. Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography. Opt Lett 1997; 22(14): 1119–1121.
81. Drexler W., Fujimoto J. Optical Coherence Tomography. Berlin, Heidelberg; 2008.
82. Yazdanfar S., Kulkarni M., Izatt J. High resolution imaging of in vivo cardiac dynamics using color Doppler optical coherence tomography. Opt Express 1997; 1(13): 424–431.
83. Levitz D., Thrane L., Frosz M., Andersen P., Andersen C., Andersson-Engels S., et al. Determination of optical scattering properties of highly-scattering media in optical coherence tomography images. Opt Express 2004; 12: 249–259.
84. van der Мееr F.J., Faber D.J., Baraznji Sassoon D.М., Aalders M.С., Pasterkamp G., van Leeuwen Т.G. Localized measurement of optical attenuation coefficients of atherosclerotic plaque constituents by quantitative optical coherence tomography. IEEE Тransactions on Medical Iмaging 2005 Oct; 24(10): 1369–1376.
85. Xu C., Schmitt J.M., Carlier S.G., Virmani R. Characterization of atherosclerosis plaques by measuring both backscattering and attenuation coefficients in optical coherence tomography. J Biomed Opt 2008; 13: 034003.
86. van Soest G., Goderie T., Regar E., Koljenovic S., van Leenders G.L., Gonzalo N., et al. Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging. J Biomed Opt 2010; 15: 011105.
87. Tearney G.J., Waxman S., Shishkov M., Vakoc B.J., Suter M.J., Freilich M.I., et al. Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging: first-in-man experience. JACC Cardiovasc Imaging 2008; 1: 752–761.
88. Izatt J.A., Kulkarni M.D., Yazdanfar S., Barton J.K., Welch A.J. In vivo bidirectional color doppler flow imaging of picoliter blood volumes using optical coherence tomography. Opt Lett 1997; 22: 1439–1441.
89. Wang X.J., Milner T.E., Nelson J.S. Characterization of fluid flow velocity by optical Doppler tomography. Opt Lett 1995; 20: 1337–1339.
90. de Boer J.F., Milner T.E., van Gemert M.J.C., Nelson J.S. Two dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography. Opt Lett 1997; 22: 934–936.
91. Everett M.J., Schoenenberger K., Colston J.B.W., Da Silva L.B. Birefringence characterization of biological tissue by use of optical coherence tomography. Opt Lett 1998; 23: 228–230.
92. Hee M.R., Huang D., Swanson E.A., Fujimoto J.G. Polarizationsensitive low-coherence reflectometer for birefringence characterization and ranging. J Opt Soc Am B 1992; 9: 903–908.
93. Applegate B.E., Izatt J.A. Molecular imaging of endogenous and exogenous chromophores using ground state recovery pump-probe optical coherence tomography. Opt Exp 2006; 14: 9142–9155.
94. Xu C., Ye J., Marks D.L., Boppart S.A. Near-infrared dyes as contrast-enhancing agents for spectroscopic optical coherence tomography. Opt Lett 2004; 29: 1647–1649.
95. Yang C., Choma M.A., Lamb L.E., Simon J.D., Izatt J.A. Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent. Opt Lett 2004; 29: 1396–1398.
96. An L., Wang R.K. In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography. Opt Exp 2008; 16: 11438–11452.
97. Park B.H., Pierce M.C., Cense B., Yun S.H., Mujat M., Tearney G.J., et al. Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 mm. Opt Exp 2005; 13: 3931–3944.
98. Szkulmowska A., Szkulmowski M., Kowalczyk A., Wojtkowski M. Phase-resolved Doppler optical coherence tomography-limitations and improvements. Opt Lett 2008; 33: 1425–1427.
99. Vakoc B.J., Yun S.H., de Boer J.F., Tearney G.J., Bouma B.E. Phaseresolved optical frequency domain imaging. Opt Exp 2005; 13: 5483–5493.
100. Oh W.Y., Vakoc B.J., Yun S.H., Tearney G.J., Bouma B.E. Single-detector polarization-sensitive optical frequency domain imaging using high-speed intra a-line polarization modulation. Opt Lett 2008; 33: 1330–1332.
101. Yamanari M., Makita S., Madjarova V.D., Yatagai T., Yasuno Y. Fiber-based polarization-sensitive fourier domain optical coherence tomography using b-scan-oriented polarization modulation method. Opt Exp 2006; 14: 6502–6515.

Gladkova N.D., Gubarkova Е.V., Sharabrin Е.G., Stelmashok V.I., Beimanov А.E. The Potential and Limitations of Intravascular Optical Coherence Tomography . Sovremennye tehnologii v medicine 2012; (4): 128