Immunomodulating and Anti-Relapse Effects of Ozone Therapy in Atopic Dermatitis in Preschool and Primary School Children
The aim of the investigation was to study the state of immunologic responsiveness, immunomodulating and anti-relapse effects of ozone therapy in children with severe extended atopic dermatitis.
Materials and Methods. We examined 64 children (38 boys and 26 girls) aged 5–10 years with severe extended atopic dermatitis. Group 1 patients (n=33) received complex standard treatment, Group 2 (n=31) — complex therapy in combination with ozone therapy.
Results. Complex standard therapy resulted in complete, though short, clinical remission; and in remission the patients preserved the changed parameters of cellular and humoral components of immune system, nonspecific resistance and the levels of pro-inflammatory cytokines in blood serum; while the patients receiving complex therapy combined with ozone therapy were found to have more rapid improvement of clinical indices, normalization of the most parameters of immunologic responsiveness and a long clinical remission.
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