Normalization of Free-Radical Oxidation Processes in Muscular Tissue in Radiation Disease by Low-Intensity Red Light Exposure in Experiment

The aim of the investigation was to assess the level of protein oxidative modification (POM) and lipid peroxidation (LP) products in muscular tissue of rats with radiation disease when exposed to low-intensity red light.

Materials and Methods. We studied the level of direct and induced POM, as well as LP parameters in rat femoral muscular tissue after ionizing radiation exposure and correction of radiation sequellae by low-intensity red light. Free-radical oxidation intensity was estimated by the content of POL products — neutral and basic aliphatic aldehyde- and cetone-dinitrophenylhydrazones; the level of LP products — diene conjugates, triene conjugates and Schiff’s bases. SPSS software application package was used for statistical processing.

Results. Rat muscular tissue showed the decreased intensity of oxidative processes — POM and LP after the ionizing radiation area had been exposed to low-intensity incoherent red light, i.e., there was the intensification of oxidative processes. The following exposure of the same area to low-intensity red light resulted in decreased level of oxidation products.

Conclusion. The exposure of biological tissues to low-intensity incoherent red light after ionizing radiation contributes to the decrease of accumulation of POM and LP products and prevents from ozidative stress development.

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Malinovskaya S.L., Ermolayev V.S., Bavrina А.P., Monich V.А. Normalization of Free-Radical Oxidation Processes in Muscular Tissue in Radiation Disease by Low-Intensity Red Light Exposure in Experiment. Sovremennye tehnologii v medicine 2014; 6(2): 32