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Synergism in Combined Use of Oral Antihyperglycemic Drugs

Synergism in Combined Use of Oral Antihyperglycemic Drugs

Sorokina Y.А., Lovtsova L.V., Bogdarina А.V., Yashanova M.I., Stcherbatyuk Т.G.
Key words: oral antihyperglycemic drugs; pharmaceutical synergism; newly diagnosed diabetes mellitus.
2014, volume 6, issue 3, page 85.

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The aim of the investigation was to study the capabilities of combined use of metformin and vildagliptin, and its effect on glycemia and oxidative stress parameters in patients with newly diagnosed type 2 diabetes mellitus (DM 2).

Materials and Methods. The study involved 37 patients with DM 2, they were divided (after two-week metformin dose titration) into two groups by simple random sampling. Group 1 patients (n=18) were administered metformin at a dose of 1700 mg a day, group 2 patients (n=19) — the combination of metformin (1000 mg a day) with vildagliptin (50 mg a day). Group 3 — a control group (n=20) consisted of subjects without carbohydrate metabolism imbalance. We studied glycemia indices (fasting blood plasma glucose, glycosylated hemoglobin), the level of molecular products of lipid peroxidation (diene and triene conjugates, malon dialdehyde), intensity of oxidative protein modification by the level of carbonyl derivatives, syperoxide dismutase and catalase activity before and 3 months after therapy.

Results. Combined use of metformin (1000 mg a day) and vildagliptin (50 mg a day) in patients with newly diagnosed DM 2 showed the synergism of their antihyperglycemic and antioxidant effect. The mentioned combination of drugs compared to metformin monotherapy (1700 mg a day) enables to reduce side effect rate and significantly increase catalase activity.

Conclusion. The results of combined use of metformin and vildagliptin demonstrated the capability of DM 2 therapy based on rational choice of the combination of antihyperglycemic drugs relying on their synergistic properties.

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Sorokina Y.А., Lovtsova L.V., Bogdarina А.V., Yashanova M.I., Stcherbatyuk Т.G. Synergism in Combined Use of Oral Antihyperglycemic Drugs. Sovremennye tehnologii v medicine 2014; 6(3): 85


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