Ozone Therapy Capabilities in Correction of Nonspecific Antimicrobial Resistance in Infantile Atopic Dermatitis

The aim of the investigation was to assess ozone therapy capabilities in the correction of nonspecific antimicrobial resistance in infantile atopic dermatitis.

Materials and Methods. 65 children (40 boys and 25 girls) aged from 8 months to 3 years with medium-severe forms of general atopic dermatitis were under observation. Group 1 patients (n=33) received complex conventional therapy, group 2 patients (n=32) — complex treatment combined with ozone therapy. We studied the content of anti-α-staphylolysin in blood serum, phagocytosis indices, the functional state of toll-like receptors (TLR-2 and TLR-6).

Results. Complex conventional therapy resulted in complete, though short-term clinical remission. When clinical remission occurred, the changes in the parameters of nonspecific antimicrobial resistance in patients with atopic dermatitis persisted. The patients receiving complex treatment combined with ozone therapy were found to have more rapid positive dynamics of clinical indices, normalization of anti-α-staphylolysin content in blood serum, phagocytosis indices, and marked function activation of toll-like receptors 2 and toll-like receptors 6, and the occurrence of a long-term clinical remission.

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Illek Ya.Yu., Galanina А.V., Isaeva N.V., Suslova Е.V., Rybakova Т.N., Fedyaeva Е.А., Kuznetsova V.V., Zaytseva G.А. Ozone Therapy Capabilities in Correction of Nonspecific Antimicrobial Resistance in Infantile Atopic Dermatitis. Sovremennye tehnologii v medicine 2014; 6(4): 167