Collost Bioplastic Collagen Material for the Treatment of Burns

The aim of the study was to evaluate the efficacy and safety of the Collost bioplastic material in the treatment of borderline and mosaic burns.

Materials and Methods. We conducted a prospective multicenter study, which included 94 patients aged 1 to 12 years with thermal skin burns (grade II–III by ICD-10). Patients were divided into four groups. In groups 1–3, various forms of the Collost bioplastic material were used (group 1 — 7% gel, group 2 — membranes, group 3 — powder) in combination with hydrocolloid dressings containing Ag⁺ ions. Patients of the control group (group 4) underwent the traditional local conservative treatment using hydrocolloid dressings alone. Concomitant therapy was similar in all of the participating centers. The total follow-up period was 4 weeks from the date of burn injury.

Results. On day 14, there were 23 cases (92%) of complete epithelization in group 1, 13 cases (68.4%) — in group 2, 21 cases (78%) — in group 3, and 9 cases (39.1%) — in group 4. The data from groups 1 and 3 significantly differed from those in control (p<0.05). The epithelialization of the burned skin in the Collost groups (7% gel and powder) was on average one week faster compared to the control.

Conclusion. The Collost bioplastic material (in the form of gel or powder) in combination with hydrocolloid dressings can be a functional and inexpensive alternative to autografts in the treatment of borderline and mosaic burns.

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Budkevich L.I., Mirzoyan G.V., Gabitov R.B., Brazol M.A., Salistyj P.V., Chikinev Y.V., Shmyrin A.A., Glutkin A.V. Collost Bioplastic Collagen Material for the Treatment of Burns. Sovremennye tehnologii v medicine 2020; 12(1): 92, https://doi.org/10.17691/stm2020.12.1.12