Hemofiltration in Patients with Severe Acute Pancreatitis (Review)

Questions regarding the application of extracorporeal detoxification to patients with severe acute pancreatitis have been considered. Hemodialysis, the historically first method of extracorporeal detoxification for such patients, has been also described in the review. Appropriateness of using renal replacement therapy methods and among them continued renal replacement therapy has been shown.

Hemofiltration and hemodiafiltration technologies are described in detail including different modes of their application and the possibility of using various types of filters. Available data on hemofiltration for patients with severe acute pancreatitis have been analyzed.

Great attention is paid to the unsolved aspects of hemofiltration in severe acute pancreatitis such as determining renal and extrarenal indices; time of starting hemofiltration; selection of volume replacement modes and a buffer system; procedure duration; anticoagulation measures, defining criteria to assess the adequacy of hemofiltration, state severity, and organ dysfunction degree.

Further multicenter investigations are necessary to be able to assess the efficacy of the hemofiltration procedures on the basis of the thoroughly worked out and pathogenically grounded protocol using adequate control methods taking into consideration endogenic intoxication phases and intensity of the multiple organ failure syndrome.

1. Russian Society of Surgeons. Hepato-Pancreato-Biliary Association of Commonwealth of Independent States. Ostryy pankreatit. Klinicheskie rekomendatsii [Acute pancreatitis. Clinical recommendations]. Moscow; 2015.
2. Savel’ev V.S., Filimonov M.I., Burnevich S.Z. Ostryy pankreatit. V kn.: Klinicheskaya khirurgiya. Natsional’noe rukovodstvo. Tom 2 [Acute pancreatitis. In: Clinical surgery. National guidelines. Vol. 2]. Moscow; 2009; p. 196–229.
3. Working Group IAP/APA Acute Pancreatitis Guidelines. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology 2013; 13(4 Suppl 2): e1–15, https://doi.org/10.1016/j.pan.2013.07.063.
4. Intensivnaya terapiya. Natsional’noe rukovodstvo [Intensive care. National guidelines]. Pod red. Gel’fanda B.R., Zabolotskikh I.B. [Gel’fand B.R., Zabolotskikh I.B. (editors)]. Moscow: GEOTAR-Media; 2017; 928 p.
5. Dellinger E.P., Forsmark C.E., Layer P., Lévy P., Maraví-Poma E., Petrov M.S., Shimosegawa T., Siriwardena A.K., Uomo G., Whitcomb D.C., Windsor J.A. Determinant based classification of acute pancreatitis severity: an international multidisciplinary consultation. Ann Surg 2012; 256(6): 875–880, https://doi.org/10.1097/sla.0b013e318256f778.
6. Ermolov A.S., Ivanov P.A., Blagovestnov D.A, Grishin A.A. Diagnostika i lechenie ostrogo pankreatita [Diagnosis and treatment of acute pancreatitis]. Moscow: VIDAR; 2013; 384 p.
7. Banks P.A., Bollen T.L., Dervenis C., Gooszen H.G., Johnson C.D., Sarr M.G., Tsiotos G.G., Vege S.S.; Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis 2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013; 62(1): 102–111, https://doi.org/10.1136/gutjnl-2012-302779.
8. Dibirov M.D., Yuanov A.A. Pankreonekroz. Protokol diagnostiki i lecheniya [Pancreatic necrosis. Diagnosis and treatment protocol]. Moscow; 2012; 366 p.
9. Dibirov M.D., Domarev L.V., Shitikov E.A., Isayev A.I., Karsotiyan G.S. Principles “cliff” pancreatic necrosis in a first-aid hospital. Khirurgiya. Zhurnal im. N.I. Pirogova 2017; 1: 73–78, https://doi.org/10.17116/hirurgia2017173-77.
10. Yang Z.H., Yang J., Wang Y.J. Protective effect of continuous veno-venous hemofiltration on tissue and organ damage in patients with severe acute pancreatitis. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2004; 16(4): 232–234.
11. Ismailov E.L., Eralina S.N., Tekesbaev B.B., Abdrasulov R.B. Extracorporeal detoxification methods in the treatment of destructive pancreatitis. Obshchaya reanimatologiya 2015; 11(3): 65–74, https://doi.org/10.15360/1813-9779-2015-3-65-74.
12. Thoeni R.F. The revised Atlanta classification of acute pancreatitis: its importance for the radiologist and its effect on treatment. Radiology 2012; 262(3): 751–764, https://doi.org/10.1148/radiol.11110947.
13. Bagnenko S.F., Savello V.E., Gol’tsov V.R. Luchevaya diagnostika zabolevaniy podzheludochnoy zhelezy: pankreatit ostryy. V kn.: Luchevaya diagnostika i terapiya v gastroenterologii: natsional’noe rukovodstvo [Radiation diagnosis of pancreatic diseases: acute pancreatitis]. Pod red. Karmazanovskogo G.G. [Karmazanovsky G.G. (editor)]. Moscow: GEOTAR-Media; 2014; p. 349–365.
14. Lohanikhina K.Iu., Hordiienko K.P., Kozarenko T.M. The role of multidetector computer tomography in diagnosis of acute pancreatitis. Klinichna khirurhiia 2014; 10: 13–15.
15. Dyuzheva T.G., Jus E.V., Shefer A.V., Akhaladze G.G., Chevokin A.Y., Kotovski A.E., Platonova L.V., Shono N.I., Galperin E.I. Pancreatic necrosis configuration and differentiated management of acute pancreatitis. Annaly hirurgiceskoj gepatologii 2013; 18(1): 92–102.
16. Freeman M.L., Werner J., van Santvoort H.C., Baron T.H., Besselink M.G., Windsor J.A., Horvath K.D., van Sonnenberg E., Bollen T.L., Vege S.S. Interventions for necrotizing pancreatitis: summary of multidisciplinary consensus conference. Pancreas 2012; 41(8): 1176–1194, https://doi.org/10.1097/mpa.0b013e318269c660.
17. Goltsov V.R., Savello V.E., Bakunov A.M., Dymnikov D.A., Kurochkin D.M., Batig E.V. Purulent-necrotic parapancreatitis: the evolution of views on treatment. Annaly khirurgicheskoy gepatologii 2015; 20(3): 75–83, https://doi.org/10.16931/1995-5464.2015375-83.
18. Andreev A.V., Ivshin V.G., Goltsov V.R. Minimally invasive interventions for infected pancreatic necrosis. Annaly khirurgicheskoy gepatologii 2015; 20(3): 110–116, https://doi.org/10.16931/1995-5464.20153110-116.
19. Shabunin A.V., Lukin A.Ju., Shikov D.V. The optimal management of acute pancreatitis depending on the “model” of pancreatic necrosis. Annaly khirurgicheskoy gepatologii 2013; 18(3): 70–78.
20. Martin-Loeches I., Levy M., Artigas A. Management of severe sepsis: advances, challenges, and current status. Drug Des Devel Ther 2015; 9: 2079–2088, https://doi.org/10.2147/dddt.s78757.
21. Takeyama Y. Significance of apoptotic cell death in systemic complications with severe acute pancreatitis. J Gastroenterol 2005; 40(1): 1–10, https://doi.org/10.1007/s00535-004-1505-8.
22. Kosovskikh A.A., Churlyaev Y.A., Kan S.L., Lyzlov A.N., Kirsanov T.V., Vartanyan A.R. Central hemodynamics and microcirculation in critical conditions. Obshchaya reanimatologiya 2013; 9(1): 18, https://doi.org/10.15360/1813-9779-2013-1-18.
23. Rudnov V.A., Kulabukhov V.V. The evolution of sepsis: the story continues. Infektsii v khirurgii 2015; 2: 6–10.
24. Rudnov V.A., Kulabukhov V.V. Sepsis and teragnostics. On the way to personified medicine. Vestnik anesteziologii i reanimatologii 2015; 12(6): 60–67.
25. Faraj T.A., McLaughlin C.L., Erridge C. Host defenses against metabolic endotoxaemia and their impact on lipopolysaccharide detection. Int Rev Immunol 2017; 36(3): 125–144, https://doi.org/10.1080/08830185.2017.1280483.
26. Vespasiani-Gentilucci U., Gallo P., Picardi A. The role of intestinal microbiota in the pathogenesis of NAFLD: starting points for intervention. Arch Med Sci 2018; 14(3): 701–706, https://doi.org/10.5114/aoms.2016.58831.
27. Pedersen C., Ijaz U.Z., Gallagher E., Horton F., Ellis R.J., Jaiyeola E., Duparc T., Russell-Jones D., Hinton P., Cani P.D., La Ragione R.M., Robertson M.D. Fecal Enterobacteriales enrichment is associated with increased in vivo intestinal permeability in humans. Physiol Rep 2018; 6(7): 16–19, https://doi.org/10.14814/phy2.13649.
28. Tsuruta M., Iwashita M., Shinjo T., Matsunaga H., Yamashita A., Nishimura F. Metabolic endotoxemia-activated macrophages promote pancreatic β cell death via IFNβ-Xaf1 pathway. Horm Metab Res 2017; 50(2): 160–167, https://doi.org/10.1055/s-0043-121467.
29. Kaukonen K.M., Bailey M., Pilcher D., Cooper D.J., Bellomo R. Systemic inflammatory response syndrome criteria in defining severe sepsis. Engl J Med 2015; 372(17): 1629–1638, https://doi.org/10.1056/nejmoa1415236.
30. Shankar-Hari M., Phillips G.S., Levy M.L., Seymour C.W., Liu V.X., Deutschman C.S., Deutschman C.S., Angus D.C., Rubenfeld G.D., Singer M.; Sepsis Definitions Task Force. Developing a new definition and assessing new clinical criteria for septic shock. JAMA 2016; 315(8): 775–787, https://doi.org/10.1001/jama.2016.0289.
31. Singer M., Deutschman C.S., Seymour C.W., Shankar-Hari M., Annane D., Bauer M., Bellomo R., Bernard G.R., Chiche J.D., Coopersmith C.M., Hotchkiss R.S., Levy M.M., Marshall J.C., Martin G.S., Opal S.M., Rubenfeld G.D., van der Poll T., Vincent J.L., Angus D.C. The Third International Consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016; 315(8): 801–810, https://doi.org/10.1001/jama.2016.0287.
32. Angus D.C., van der Poll T. Severe sepsis and septic shock. N Engl J Med 2013; 369(9): 840–851, https://doi.org/10.1056/nejmra1208623.
33. Casserly B., Phillips G.S., Schorr C., Dellinger R.P., Townsend S.R., Osborn T.M., Reinhart K., Selvakumar N., Levy M.M. Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med 2015; 43(3): 567–573, https://doi.org/10.1097/ccm.0000000000000742.
34. Musselius S.G. Sindrom endogennoy intoksikatsii pri neotlozhnykh sostoyaniyakh [Endogenous intoxication syndrome in emergency conditions]. Moscow: BINOM; 2008; 200 p.
35. Moroz V.V., Golubev A.M. Sepsis: principles of diagnosis. Obshchaya reanimatologiya 2013; 9(6): 57, https://doi.org/10.15360/1813-9779-2013-6-5.
36. Agapov K.V., Shutov A.A., Polyvoda M.D., Pavlov N.B., Bagdatieva M.G. Use of somatostatin analogues in the pancreonecrosis therapy (clinical and experimental research). Khirurgiya. Zhurnal im. N.I. Pirogova 2016; 12: 71–76, https://doi.org/10.17116/hirurgia20161271-76.
37. Sandakov P.Ya., Samartsev V.A., Mineev D.A. Surgical and therapeutic treatment of acute pancreatitis. Khirurgiya. Zhurnal im. N.I. Pirogova 2014; 10: 56–63.
38. Shukevich D.L. Prodlennaya zamestitel’naya pochechnaya terapiya pri abdominal’nom sepsise. Avtoref. dis. … dokt. med. nauk [Extended renal replacement therapy for abdominal sepsis. DSc Thesis]. Moscow; 2010.
39. Berezhnoy S.G., Lukach V.N., Tsygankov P.V., Malaya N.S., Furmanova T.Yu. Assessment of oxygen status in critical patients with systemic inflammatory reaction. Anesteziologiya i reanimatologiya 2013; 3: 35–40.
40. Matveyev S.B., Klytchnikova E.V., Grishin A.V., Bogdanova A.S., Godkov M.A. The comparative characteristic of coefficients of endogenic intoxication under severe acute pancreatitis. Klinicheskaya laboratornaya diagnostika 2013; 5: 5–7.
41. Vinokurov M.M., Savel’ev V.V., Khlebnyy E.S., Kershengol’ts B.M. The evaluation of the endogenous intoxication level in the sterile phase of pancreonecrosis. Khirurgiya. Zhurnal im. N.I. Pirogova 2012; 10: 21–26.
42. Mikhaylusov S.V., Smirnova N.A, Vorob’eva E.A., Bogdanova L.S., Moiseenkova E.V., Eshtrekov M.S. Laboratory diagnosis of infected pancreonecrosis. Klinicheskaya laboratornaya diagnostika 2010; 11: 3–7.
43. Vinokurov M.M., Savel’ev V.V., Khlebnyy E.S., Kershengol’ts B.M. Prognostic value of peroxidase and antioxidant systems in patients with sterile pancreonecrosis. Khirurgiya. Zhurnal im. N.I. Pirogova 2010; 12: 38–43.
44. Ronco C., D’lntini V., Bellomo R., Ricci Z., Bonello M., Ratanarat R., Salvatori G., Bordoni V., Andrikos E., Brendolan A. Rationale for the use of extracorporeal treatment for sepsis. Anesteziologiya i reanimatologiya 2005; 2: 87–90.
45. Panagiotou A., Gaiao S., Cruz D.N. Extracorporeal therapies in sepsis. J Intensive Care Med 2011; 28(5): 281–295, https://doi.org/10.1177/0885066611425759.
46. Cui Y., Xiong X., Wang F., Ren Y., Wang C., Zhang Y. Continuous hemofiltration improves the prognosis of bacterial sepsis complicated by liver dysfunction in children. BMC Pediatr 2018; 18(1): 269, https://doi.org/10.1186/s12887-018-1243-3.
47. Li W.B., Yin L.Y., Zhang X.Q. Evaluation of safety and efficacy of different continuous blood Purification methods in treating infantile sepsis. J Biol Regul Homeost Agents 2018; 32(3): 663–667.
48. Liu Y., Chen X., Wang D., Li H., Huang J., Zhang Z., Qiao Y., Zhang H., Zeng Y., Tang C., Yang S., Wan X., Chen Y.H., Zhang Y. Hemofiltration successfully eliminates severe cytokine release syndrome following CD19 CAR-T-Cell. J Immunother 2018; 41(9): 406–410, https://doi.org/10.1097/cji.0000000000000243.
49. Alobaidi R., Basu R.K., Goldstein S.L., Bagshaw S.M. Sepsis-associated acute kidney injury. Semin Nephrol 2015; 35(1): 2–11, https://doi.org/10.1016/j.semnephrol.2015.01.002.
50. Shum H., Yan W., Chan T. Extracorporeal blood purification for sepsis. Hong Kong Med J 2016; 22(5): 478–485, https://doi.org/10.12809/hkmj164876.
51. Khoroshilov S.E., Nikulin A.V. Detoxication in critical conditions: an insight into the scientific problem in the XXI century (review). Obshchaya reanimatologiya 2017; 13(5): 85–108, https://doi.org/10.15360/1813-9779-2017-5-85-108.
52. Khoroshilov S.E., Pavlov R.E., Smirnova S.G., Il’chenko A.M. High volume hemofiltration in the treatment of sepsis and septic shock. Al’manakh anesteziologii i reanimatologii 2007; 3: 63.
53. Atan R., Peck L., Prowle J., Licari E., Eastwood G.M., Storr M., Goehl H., Bellomo R. A double-blind randomized controlled trial of high cutoff versus standard hemofiltration in critically ill patients with acute kidney injury. Crit Care Med 2018; 46(10): e988–e994, https://doi.org/10.1097/ccm.0000000000003350.
54. Ronco C. Evolution of technology for continuous renal replacement therapy: forty years of improvement: forty years of improvement. Contrib Nephrol 2018; 194: 1–14.
55. Ricci Z., Romagnoli S., Ronco C., La Manna G. From continuous renal replacement therapies to multiple organ support therapy. Contrib Nephrol 2018; 194: 155–169, https://doi.org/10.1159/000485634.
56. Poz Y.L., Strokov A.G., Kopylova Y.V. Hemodiafiltration. History, evolution, contemporary standards. Vestnik transplantologii i iskusstvennykh organov 2014; 16(1): 54–64, https://doi.org/10.15825/1995-1191-2014-1-54-64.
57. Khoroshilov S.E., Nikulin A.V., Marukhov A.V. Use of plasmapheresis in the enzymatic phase of severe acute pancreatitis. Obshchaya reanimatologiya 2013; 9(6): 53–60, https://doi.org/10.15360/1813-9779-2013-6-53.
58. Gyulazyan N.M., Belaya O.F., Malov V.A., Pak S.G., Volchkova E.V. Lipopolysaccharides/endotoxins of gram-negative bacteria: their role in the developing intoxication. Epidemiologiya i infektsionnye bolezni 2014; 2: 11–16.
59. Khoroshilov S.E., Beloborodova N.V., Nikulin A.V., Bedova A.Yu. Impact of extracorporeal detoxification on the serum levels of microbial aromatic acid metabolites in sepsis. Obshchaya reanimatologiya 2015; 11(5): 6–14, https://doi.org/10.15360/1813-9779-2015-5-6-14.
60. Gagua A.K., Ivanenkov I.M., Vorob’ev P.Yu. Opportunities for volatile fatty acids using in early diagnostics of infected pancreonecrosis. Khirurgiya. Zhurnal im. N.I. Pirogova 2014; 11: 6–13.
61. Liu B., Chen Y.X., Yin Q., Zhao Y.Z., Li C.S. Diagnostic value and prognostic evaluation of Presepsin for sepsis in an emergency department. Crit Care 2013; 17(5): 244, https://doi.org/10.1186/cc13070.
62. Dai S.R., Li Z., Zhang J.B. Serum interleukin 17 as an early prognostic biomarker of severe acute pancreatitis receiving continuous blood purification. Int J Artif Organs 2015; 38(4): 192–198, https://doi.org/10.5301/ijao.5000406.
63. He C., Zhang L., Shi W., Liang X., Ye Z., Zhang B., Liu S. Coupled plasma filtration adsorption combined with continuous veno-venous hemofiltration treatment in patients with severe acute pancreatitis. J Clin Gastroenterol 2013; 47(1): 62–68, https://doi.org/10.1097/mcg.0b013e318266f455.
64. Zhang J., Yuan C., Hua G., Tong R., Luo X., Ying Z. Early gut barrier dysfunction in patients with severe acute pancreatitis: attenuated by continuous blood purification treatment. Int J Artif Organs 2010; 33(10): 706–715, https://doi.org/10.1177/039139881003301003.
65. Li M., Shi Z., Xu J., Lu B., Li J., Xu Y., Wang X.M., Li S.M., Mo X. Haemodiafiltration combined with resin-mediated adsorption as a therapy for hyperlipidemic acute pancreatitis. Cell Biochem Biophys 2014; 69(3): 699–702, https://doi.org/10.1007/s12013-014-9855-1.
66. Honoré P.M., Joannes-Boyau О., Gressens В. Blood and plasma treatments: the rationale of high-volume hemofiltration. Contrib Nephrol 2007; 156: 387–395, https://doi.org/10.1159/000102129.
67. Honoré P.M., Joannes-Boyau О., Boer W., Collin V. High-volume hemofiltration in sepsis and SIRS: current concepts and future prospects. Blood Purif 2009; 28: 1–11, https://doi.org/10.1159/000210031.
68. Ronco C. Recent evolution of renal replacement therapy in critically ill patient. Crit Care 2006; 10: 123.
69. Ronco С., Bellomo R., Kellum J. Critical care nephrology. Saunders; 2009; 1848 p.
70. Ronco C., Bellomo R., Homel P., Brendolan A., Dan M., Piccinni P., La Greca G. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet 2000; 356(9223): 26–30, https://doi.org/10.1016/s0140-6736(00)02430-2.
71. Ronco C., Bellomo R. Acute renal failure and multiple organ dysfunction in the ICU: from renal replacement therapy (RRT) to multiple organ support therapy (MOST). Int J Artif Organs 2002; 25(8): 733–747, https://doi.org/10.1177/039139880202500801.
72. Kudryavtsev A.N. Vybor rezhima gemofil’tratsii kak komponenta intensivnoy terapii tyazhelogo sepsisa. Avtoref. dis. … kand. med. nauk [The choice of hemofiltration regimen as a component of intensive therapy for severe sepsis. PhD Thesis]. Moscow; 2016.
73. Kudryavtsev A.N., Kulabukhov V.V., Chizhov A.G. The selection of hemofiltration regimen in sepsis. Obshchaya reanimatologiya 2016; 12(2): 43–55.
74. Chen L.X., Demirjian S., Udani S.M., Trevino S.A., Murray P.T., Koyner J.L. Cytokine clearances in critically ill patients on continuous renal replacement therapy. Blood Purif 2018; 46(4): 315–322, https://doi.org/10.1159/000492025.
75. Jiang H.L., Xue W.J., Li D.Q., Yin A.P., Xin X., Li C.M., Gao J.L. Influence of continuous veno-venous hemofiltration on the course of acute pancreatitis. World J Gastroenterol 2005; 11(31): 4815–4821, https://doi.org/10.3748/wjg.v11.i31.4815.
76. Khoroshilov S.E., Marukhov A.V. Prevention of lung injury at enzyme phase of severe acute pancreatitis. Trudnyy patsient 2013; 11(10): 33–37.
77. You B., Zhang Y.L., Luo G.X., Dang Y.M., Jiang B., Huang G.T., Liu X.Z., Yang Z.C., Chen Y., Chen J., Yuan Z.Q., Yin S.P., Peng Y.Z.. Early application of continuous high-volume haemofiltration can reduce sepsis and improve the prognosis of patients with severe burns. Crit Care 2018; 22(1): 173, https://doi.org/10.1186/s13054-018-2095-9.
78. Xu X., Dai H., Jia C., Wang C. Extracorporeal blood therapy in sepsis and acute respiratory distress syndrome: the “purifying dream”. Chin Med J 2014; 127(24): 4263–4270.
79. Bagnenko S.F., Gromov M.I. The use of plasma therapy and hemofiltration for treatment of multiple organ failure. Efferentnaya terapiya 2009; 15(3–4): 19–27.
80. Ostryy respiratornyy distress-sindrom: klassifikatsiya, diagnostika, differentsirovannoe lechenie [Acute respiratory distress syndrome: classification, diagnosis, differentiated treatment]. Pod red. Moroz V.V. [Moroz V.V. (editor)]. Moscow: NIIOR RAMN; 2013.
81. Mukhoedova T.V. Kriterii initsiatsii zamestitel’noy pochechnoy terapii pri kriticheskikh sostoyaniyakh [Criteria for initiating renal replacement therapy in critical conditions]. Novosibirsk; 2011.
82. Kurihara Y., Ueki S., Kokubo K., Kobayashi Y., Ebine T., Murakami K., Ushiroda Y., Maruyama N., Tsukao H., Kobayashi K., Kobayashi H. Continuous hemofiltration model using porcine blood for comparing filter life. J Artif Organs 2018; 21(3): 332–339, https://doi.org/10.1007/s10047-018-1060-3.
83. Bazhina E.S., Nikulin A.V., Khoroshilov S.E. Extracorporeal treatments for abdominal sepsis. Obshchaya reanimatologiya 2015; 11(5): 45–66, https://doi.org/10.15360/1813-9779-2015-5-45-66.
84. Vlasov A.P., Bunyatyan N.D., Grigoryeva T.I., Bykhanova O.N., Anaskin S.G., Rakhmetullova G.R., Khaurova O.A. Correction of systemic inflammatory response syndrome in surgical endotoxicosis. Farmatsiya 2012; 5: 44–48.
85. Reinhart K., Meisner M. Biomarkers in the critically ill patient: procalcitonin. Crit Care Clin 2011; 27(2): 253–263, https://doi.org/10.1016/j.ccc.2011.01.002.
86. Wong H.R., Walley K.R., Pettilä V., Meyer N.J., Russell J.A., Karlsson S., Shashaty M.G., Lindsell C.J. Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock. Biomarkers 2015; 20(2): 132–135, https://doi.org/10.3109/1354750x.2014.1000971.
87. Yaroustovsky M., Abramyan M., Krotenko N., Popov D., Plyushch M., Rogalskaya E. A pilot study of selective lipopolysaccharide adsorption and coupled plasma filtration and adsorption in adult patients with severe sepsis. Blood Purif 2015; 39(1–3): 210–217, https://doi.org/10.1159/000371754.
88. Haase M., Bellomo R., Baldwin I., Haase-Fielitz A., Fealy N., Davenport P., Morgera S., Goehl H., Storr M., Boyce N., Neumayer H.H. Hemodialysis membrane with a high-molecular-weight cutoff and cytokine levels in sepsis complicated by acute renal failure: a phase 1 randomized trial. Am J Kidney Dis 2007; 50(2): 296–304, https://doi.org/10.1053/j.ajkd.2007.05.003.
89. Dagher G.A., Saadeldine M., Bachir R., Zebian D., Chebl R.B. Descriptive analysis of sepsis in a developing country. Int J Emerg Med 2015; 8: 19, https://doi.org/10.1186/s12245-015-0068-1.
90. Tattersall J.E., Ward R.A.; EUDIAL group. Online haemodiafiltration: definition, dose quantification and safety revisited. Nephrol Dial Transplant 2013; 28(3): 542–550, https://doi.org/10.1093/ndt/gfs530.
91. Khoroshilov S.E., Nikulin A.V. Efferent treatment for critical conditions. Obshchaya reanimatologiya 2012; 8(4): 30–41, https://doi.org/10.15360/1813-9779-2012-4-30.
92. Bellomo R., Ronco C. Continuous haemofiltration in the intensive care unit. Crit Care 2000; 4(6): 339–345.
93. Mehta R.L. Indications for dialysis in the ICU: renal replacement vs. renal support. Blood Purif 2001; 19(2): 227–232, https://doi.org/10.1159/000046946.
94. Moroz V.V., Grigor’ev E.V., Churlyaev Yu.A. Abdominal’nyy sepsis [Abdominal sepsis]. Moscow; 2006.
95. Bagnenko S.F., Tolstoy A.D., Krasnorogov V.B., Kurygin A.A., Sinenchenko G.I., Sukharev V.F., Grinev M.V., Lapshin V.N., Verbitskiy V.G., Kiselev V.A., Kabanov M.Yu., Gol’tsov V.R. Ostryy pankreatit (protokoly diagnostiki i lecheniya). [Acute pancreatitis (diagnostic and treatment protocols)]. Saint Petersburg; 2004.
96. Ermolov A.S., Ivanov P.A., Belyaev A.A. Rol’ maloinvazivnykh vmeshatel’stv pri lechenii ostrogo pankreatita. V kn.: Materialy gorodskogo seminara [The role of minimally invasive interventions in the treatment of acute pancreatitis. In: Proceedings of the city seminar]. Moscow: NII skoroy pomoshchi im. N.V. Sklifosovskogo; 2003; p. 5–9.
97. Gostishchev V.K., Glushko V.A. Pancreatic necrosis and its complications. The basic principles of surgical tactics. Khirurgiya. Zhurnal im. N.I. Pirogova 2003; 3: 50–54.
98. Gorskiy V.A., Koval’chuk L.V., Agapov M.A., Khoreva M.V., Ovanesian E.R., Nikonova A.S., Grechenko V.V. Antimediatory therapy in the complex treatment of acute destructive pancreatitis. Khirurgiya. Zhurnal im. N.I. Pirogova 2010; 3: 54–61.
99. Beger H.G., Rau B., Isenmann R. Natural history of necrotizing pancreatitis. Pancreatology 2003; 3(2): 93–101, https://doi.org/10.1159/000070076.
100. Popova E.Yu., Kuznetsov N.A., Vladimirov V.G., Zarinskaya S.A., Andreytsev A.N., Brontveyn A.T., Kuzin A.N. Damage to retroperitoneal tissue in destructive pancreatitis. Khirurgiya. Zhurnal im. N.I. Pirogova 2004; 8: 52–55.
101. Buter A., Imrie C.W., Carter C.R., Evans S., McKay C.J. Dynamic nature of early organ dysfunction determines outcome in acute pancreatitis. Br J Surg 2002; 89(3): 298–302, https://doi.org/10.1046/j.0007-1323.2001.02025.x.
102. La Manna G., Donati G. Coupled plasma filtration adsorption: a multipurpose extracorporeal detoxification therapy. Blood Purif 2018; 46(3): 228–238, https://doi.org/10.1159/000490234.
103. Broman M., Bell M., Joannes-Boyau O., Ronco C. The novel PrisMax continuous renal replacement therapy system in a multinational, multicentre pilot setting. Blood Purif 2018; 46(3): 220–227, https://doi.org/10.1159/000489213.
104. Zaporozhchenko B.S., Korytna H.Iu., Muraviov P.T., Sharapov I.V. Influence of membrane plasmapheresis on the course of endotoxemia in acute destructive pancreatitis. Klinichna khirurhiia 2013; 9: 26–28.
105. Wang H., Li W.Q., Zhou W., Li N., Li J.S. Clinical effects of continuous high volume hemofiltration on severe acute pancreatitis complicated with multiple organ dysfunction syndrome. World J Gastroenterol 2003; 9(9): 2096–2099, https://doi.org/10.3748/wjg.v9.i9.2096.
106. Abulimiti A., Husaiyin A., Sailai Y. Evaluation of HVHF for the treatment of severe acute pancreatitis accompanying MODS. Medicine 2018; 97(1): e9417, https://doi.org/10.1097/md.0000000000009417.
107. Klouche K., Amigues L., Morena M., Brunot V., Dupuy A.M., Jaussent A., Picot M.C., Besnard N., Daubin D., Cristol J.P. On-line hemodiafiltration did not induce an overproduction of oxidative stress and inflammatory cytokines in intensive care unit-acute kidney injury. BMC Nephrol 2017; 18(1): 371, https://doi.org/10.1186/s12882-017-0785-1.
108. Petrov V.S., Petrova M.M., Sviridov S.V., Surmenev D.V. Extracorporeal haemocorrection and its impact on free-radical oxidation and antioxidant defense in abdominal sepsis. Vestnik anesteziologii i reanimatologii 2018; 15(1): 40–45, https://doi.org/10.21292/2078-5658-2018-15-1-40-45.
109. Rodnikov S.E. Nizkopotochnaya ul’tragemofil’tratsiya i nepryamoe elektrokhimicheskoe okislenie krovi v kompleksnom lechenii pankreonekroza. Avtoref. dis. … kand. med. nauk [Low-flow ultrahemofiltration and indirect electrochemical oxidation of blood in the complex treatment of pancreatic necrosis. PhD Thesis]. Moscow; 2010.
110. Miao H., Wang F., Xiong X., Wang C., Zhang Y. Clinical benefits of high-volume hemofiltrationin critically ill pediatric patients with severe sepsis: a retrospective cohort study. Blood Purif 2018; 45(1–3): 18–27, https://doi.org/10.1159/000481249.
111. Bellomo R., Baldwin I., Naka Т., Wan L., Fealy N., Ronco C. Long-term intermittent renal replacement therapy in the intensive care unit. Anesteziologiya i reanimatologiya 2005; 2: 74–78.
112. Guo J., Huang W., Yang X.N., Jin T., Altaf K., Javed M.A., Lin Z.Q., Huang Z.W., Xue P., Johnstone M., Sutton R., Xia Q. Short-term continuous high-volume hemofiltration on clinical outcomes of severe acute pancreatitis. Pancreas 2014; 43(2): 250–254, https://doi.org/10.1097/01.mpa.0000437321.06857.fc.
113. Xu J., Zhao J., Jia X., Wang G. Application of early continuous renal replacement therapy in the bundle treatment of severe рneumonia. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018; 30(3): 246–250.
114. Rosner M.H., Connor M.J. Jr. Management of severe hyponatremia with continuous renal replacement therapies. Clin J Am Soc Nephrol 2018; 13(5): 787–789, https://doi.org/10.2215/cjn.13281117.
115. Vatazin A.V., Fomin A.M., Koshelev V.V., Chemeris A.N., Stroiteleva E.M., Yankovoy A.G., Nguen D.K. Prolonged low-flow veno-venous hemofiltration in peritonitis: dynamics of the severity of endotoxemia as a criterion for the effectiveness of the method. Anesteziologiya i reanimatologiya 2005; 2: 66–69.
116. Xu J., Cui Y., Tian X. Early continuous veno-venous hemofiltration is effective in decreasing intra-abdominal pressure and serum interleukin-8 level in severe acute pancreatitis patients with abdominal compartment syndrome. Blood Purif 2017; 44(4): 276–282, https://doi.org/10.1159/000480223.
117. Pupelis G., Plaudis H., Zeiza K., Drozdova N., Mukans M., Kazaka I. Early continuous veno-venous haemofiltration in the management of severe acute pancreatitis complicated with intra-abdominal hypertension: retrospective review of 10 years’ experience. Ann Intensive Care 2012; 2(Suppl 1): S21, https://doi.org/10.1186/2110-5820-2-s1-s21.
118. Il’inskiy M.E. Postoyannaya veno-venoznaya gemofil’tratsiya v kompleksnom lechenii bol’nykh tyazhelym ostrym pankreatitom. Avtoref. dis. … kand. med. nauk [Constant veno-venous hemofiltration in the complex treatment of patients with severe acute pancreatitis. PhD Thesis]. Moscow; 2012.
119. Xu J., Tian X., Zhang C., Wang M., Li Y. Management of abdominal compartment syndrome in severe acute pancreatitis patients with early continuous veno-venous hemofiltration. Hepatogastroenterology 2013; 60(127): 1749–1752.
120. Li P., Qu L.P., Qi D., Shen B., Wang Y.M., Xu J.R., Jiang W.H., Zhang H., Ding X.Q., Teng J. High-dose versus low-dose haemofiltration for the treatment of critically ill patients with acute kidney injury: an updated systematic review and meta-analysis. BMJ Open 2017; 7(10): e014171, https://doi.org/10.1136/bmjopen-2016-014171.
121. Zhang X., Sun S., Li S., Feng X., Wang S., Liu C., Hang Z., Tong C., Zhu C., Bai B., Xu B., Feng Q., Zhao Q. Early classic hemofiltration exhibits no benefits in severe acute pancreatitis with early organ failure: a retrospective case-matched study. Artif Organs 2014; 38(4): 335–341, https://doi.org/10.1111/aor.12159.
122. Wang S., Xu L., Feng X., Li S., Feng Q., Liu C., Zhang X., Zhao Q. Is continuous venovenous hemofiltration effective against severe acute pancreatitis? Artif Organs 2013; 37(7): 615–622, https://doi.org/10.1111/aor.12051.
123. Meng S.Q., Yang W.B., Liu J.G., Yuan J.Y., Zhang K., Ding W.Y., Yang S.Q., Liu J.H. Evaluation of the application of high volume hemofiltration in sepsis combined with acute kidney injury. Eur Rev Med Pharmacol Sci 2018; 22(3): 715–720.
124. Abdelsalam M.S., Rashwan M., Althaf M.M., Alfurayh O.I., Alkorbi L., Ibrahim I.A. Comparison of survival between dialysis patients with incident high-flux hemodialysis versus on-line hemodiafiltration: a single center experience in Saudi Arabia. Saudi J Kidney Dis Transpl 2018; 29(1): 107–113, https://doi.org/10.4103/1319-2442.225191.
125. Biryukova L.S., Purlo N.V., Denisova E.N., Mondoev L.G., Levina A.A., Galstyan G.M. The use of continuous high volume hemodiafiltration in patients with sepsis and multiple organ failure. Anesteziologiya i reanimatologiya 2005; 2: 69–72.
126. Chung K.K., Coates E.C., Smith D.J. Jr., Karlnoski R.A., Hickerson W.L., Arnold-Ross A.L., Mosier M.J., Halerz M., Sprague A.M., Mullins R.F., Caruso D.M., Albrecht M., Arnoldo B.D., Burris A.M., Taylor S.L., Wolf S.E. High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial. Crit Care 2017; 21(1): 289, https://doi.org/10.1186/s13054-017-1878-8.
127. Yamashita T., Horibe M., Sanui M., Sasaki M., Sawano H., Goto T., Ikeura T., Hamada T., Oda T., Yasuda H., Ogura Y., Miyazaki D., Hirose K., Kitamura K., Chiba N., Ozaki T., Koinuma T., Oshima T., Yamamoto T., Hirota M., MasudaY., Tokuhira N., Kobayashi M., Saito S., Izai J., Lefor A.K., Iwasaki E., Kanai T., Mayumi T. Large volume fluid resuscitation for severe acute pancreatitis is associated with reduced mortality: a multicenter retrospective study. J Clin Gastroenterol 2019; 53(5): 385–391, https://doi.org/10.1097/mcg.0000000000001046.
128. Liu C., Li M., Cao S., Wang J., Huang X., Zhong W. Effects of HV-CRRT on PCT, TNF-α, IL-4, IL-6, IL-8 and IL-10 in patients with pancreatitis complicated by acute renal failure. Exp Ther Med 2017; 14(4): 3093–3097, https://doi.org/10.3892/etm.2017.4843.
129. Sun S., He L., Bai M., Liu H., Li Y., Li L., Yu Y., Shou M., Jing R., Zhao L., Huang C., Wang H. High-volume hemofiltration plus hemoperfusion for hyperlipidemic severe acute pancreatitis: a controlled pilot study. Ann Saudi Med 2015; 35(5): 352–358, https://doi.org/10.5144/0256-4947.2015.352.
130. Joannes-Boyau O., Honoré P.M., Perez P., Bagshaw S.M., Grand H., Canivet J.L., Dewitte A., Flamens C., Pujol W., Grandoulier A.S., Fleureau C., Jacobs R., Broux C., Floch H., Branchard O., Franck S., Rozé H., Collin V., Boer W., Calderon J., Gauche B., Spapen H.D., Janvier G., Ouattara A. High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial. Intensive Care Med 2013; 39(9): 1535–1546, https://doi.org/10.1007/s00134-013-2967-z.
131. Combes A., Bréchot N., Amour J., Cozic N., Lebreton G., Guidon C., Zogheib E., Thiranos J.C., Rigal J.C., Bastien O., Benhaoua H., Abry B., Ouattara A., Trouillet J.L., Mallet A., Chastre J., Leprince P., Luyt C.E. Early high-volume hemofiltration versus standard care for post-cardiac surgery shock. The HEROICS study. Am J Respir Crit Care Med 2015; 192(10): 1179–1190, https://doi.org/10.1164/rccm.201503-0516oc.
132. Berdnikov A.P., Goncharenko S.I., Musaeva T.S., Zabolotskikh I.B. Intracranial pressure during high-volume hemofiltration in severe sepsis. Obshchaya reanimatologiya 2014; 10(6): 39–45, https://doi.org/10.15360/1813-9779-2014-6-39-45.
133. Aleksandrova I.V., Ilyinskiy M.Ye., Rey S.I., Berdnikov G.A., Marchenkova L.V. Permanent vein to vein hemofiltration in the complex therapy of severe acute pancreatitis. Anesteziologiya i reanimatologiya 2011; 3: 54–58.
134. Bollmann M.D., Revelly J.P., Tappy L., Berger M.M., Schaller M.D., Cayeux M.C., Martinez A., Chioléro R.L. Effect of bicarbonate and lactate buffer on glucose and lactate metabolism during hemodiafiltration in patients with multiple organ failure. Intensive Care Med 2004; 30(6): 1103–1110, https://doi.org/10.1007/s00134-004-2251-3.
135. Schmitz M., Joannidis M., Czock D., John S., Jörres A., Klein S.J., Oppert M., Schwenger V., Kielstein J., Zarbock A., Kindgen-Milles D., Willam C. Regional citrate anticoagulation in renal replacement therapy in the intensive care station: recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI. Med Klin Intensivmed Notfmed 2018; 113(5): 377–383, https://doi.org/10.1007/s00063-018-0445-7.
136. Wu B., Wang J., Yang G., Xing C., Mao H. Rapid calcium loss may cause arrhythmia in hemofiltration with regional citrate anticoagulation: a case report. BMC Nephrol 2018; 19(1): 136, https://doi.org/10.1186/s12882-018-0936-z.
137. Chan K.-C., Yan W.-W., Shum H.-P., Chan T. Treatment of acute kidney injury complicating septic shock with EMiC2 high-cutoff hemofilter: case series. Indian J Crit Care Med 2017; 21(11): 751–757, https://doi.org/10.4103/ijccm.ijccm_338_17.
138. Eremeyeva L.F., Menshchikov V.V., Berdnikov A.P., Yampolsky A.F. Lipid on-line hemodiafiltration (experimental study). Obshchaya reanimatologiya 2013; 9(1): 37–42, https://doi.org/10.15360/1813-9779-2013-1-37.
139. Maeda H., Tomisawa N., Jimbo Y., Harii N., Matsuda K. Efficacy of hemofiltration with PEPA membrane for IL-6 removal in a rat sepsis model. J Artif Organs 2017; 20(4): 335–340, https://doi.org/10.1007/s10047-017-0991-4.
140. Lutfarakhmanov I.I., Mironov P.I. Diagnostic and prognostic significance of severity assessment systems in acute destructive pancreatitis. Klinicheskaya anesteziologiya i reanimatologiya 2005; 2(4): 26–36.
141. Harshit Kumar A., Singh Griwan M. A comparison of APACHE II, BISAP, Ranson’s score and modified CTSI in predicting the severity of acute pancreatitis based on the 2012 revised Atlanta Classification. Gastroenterol Rep (Oxf) 2018; 6(2): 127–131, https://doi.org/10.1093/gastro/gox029.
142. Matveev S.B., Ivanov P.A., Golikov P.P., Davydov B.V., Grishin A.V., Berdnikov G.A., Kpychnikova E.V., Nikolaeva N.Yu. Evaluation criteria for endogenous intoxication in pancreatic necrosis. Vestnik intensivnoy terapii 2004; 2: 69–70.
143. Barauskas G., Svagzdys S., Maleckas A. C-reactive protein in early prediction of pancreatic necrosis. Medicina 2004; 40(2): 135–140.
144. Kupčinskas J., Gedgaudas R., Hartman H., Sippola T., Lindström O., Johnson C., Regnér S. Intestinal fatty acid binding protein as a marker of necrosis and severity in acute pancreatitis. Pancreas 2018; 47(6): 715–720, https://doi.org/10.1097/mpa.0000000000001068.
145. Orlov Yu.P., Govorova N.V., Glushchenko A.V., Kolyadko A.V., Nochnaya Yu.A. Acute pancreatitis from anaesthesiologist-reanimatologist point of view: comments to the Russian guidelines for the treatment of acute pancreatitis. Vestnik intensivnoy terapii 2016; 4: 34–40.
146. Ryabkov M.G., Izmaylov S.G., Lukoyanychev E.E., Sabauri R.V., Orlinskaya N.Yu. Intraabdominal hypertension in patients with acute conditions of abdominal cavity. Khirurgiya. Zhurnal im. N.I. Pirogova 2013; 3: 48–54.
147. Zubritskiy V.F., Zabelin M.V., Levchuk A.L., Pokrovskiy K.A., Ryabov A.L., Bagdosarov R.B. Diagnostics and treatment of intra-abdominal hypertension for patients suffering from abdominal sepsis. Vestnik Natsional’nogo mediko-khirurgicheskogo Tsentra im. N.I. Pirogova 2010; 5(3): 61–64.
148. Rajbuzhis E.N., Fot E.V., Gaidukov K.M., Kirov M.Yu. Monitoring of intraabdominal pressure and abdominal perfusion pressure in urgent abdominal surgery. Anesteziologiya i reanimatologiya 2014; 3: 17–20.
149. Vinnik Y.S., Repina E.V., Serova E.V., Repin A.S., Chavkunkin F.P., Gabrielyan A.A., Zhuravlev M.O. Urodynamic abnormalities in the kidneys of pancreonecrosis. Vestnik Rossiyskoy akademii meditsinskikh nauk 2014; 69(1–2): 19–21.
150. Boone B., Zureikat A., Hughes S.J., Moser A.J., Yadav D., Zeh H.J., Lee K.K. Abdominal compartment syndrome is an early, lethal complication of acute pancreatitis. Am Surg 2013; 79(6): 601–607.
151. Malbrain M.L., Cheatham M.L., Kirkpatrick A., Sugrue M., Parr M., De Waele J., Balogh Z., Leppäniemi A., Olvera C., Ivatury R., D’Amours S., Wendon J., Hillman K., Johansson K., Kolkman K., Wilmer A. Results from the international conference of experts on intra-abdominal hypertension and abdominal compartment syndrome. I. Definitions. Intensive Care Med 2006; 32(11): 1722–1732.
152. Ball C.G., Kirkpatrick A.W. Intra-abdominal and abdominal compartment syndrome. Scand J Surg 2007; 17: 197–204.
153. Kirkpatrick A.W., Roberts D.J., De Waele J., Jaeschke R., Malbrain M.L., De Keulenaer B., Duchesne J., Bjorck M., Leppaniemi A., Ejike J.C., Sugrue M., Cheatham M., Ivatury R., Ball C.G., Reintam Blaser A., Regli A., Balogh Z.J., D’Amours S., Debergh D., Kaplan M., Kimball E., Olvera C. Intra-abdominal hypertension and the abdominal compartment syndrome: updates consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome. Intensive Care Med 2013; 39(17): 1190–1206, https://doi.org/10.1007/s00134-013-2906-z.
154. Chu L.P., Zhou J.J., Yu Y.F., Huang Y., Dong W.X. Clinical effects of pulse high-volume hemofiltration on severe acute pancreatitis complicated with multiple organ dysfunction syndrome. Ther Apher Dial 2013; 17(1): 78–83, https://doi.org/10.1111/j.1744-9987.2012.01104.x.
155. Zhu Y., Yuan J., Zhang P., Hu X., He Q., Han F., Chen J. Adjunctive continuous high-volume hemofiltration in patients with acute severe pancreatitis: a prospective nonrandomized study. Pancreas 2011; 40(1): 109–113, https://doi.org/10.1097/mpa.0b013e3181f83019.
156. Souza G.D., Souza L.R., Cuenca R.M., Jerônimo B.S., Souza G.M., Vilela V.M. Understanding the international consensus for acute pancreatitis: classification of Atlanta 2012. Arq Bras Cir Dig 2016; 29(3): 206–210, https://doi.org/10.1590/0102-6720201600030018.

Boyarinov G.А., Zubeyev P.S., Mokrov К.V., Voyennov О.V. Hemofiltration in Patients with Severe Acute Pancreatitis (Review). Sovremennye tehnologii v medicine 2020; 12(1): 105, https://doi.org/10.17691/stm2020.12.1.14