Efficacy of Poly-3-Hydroxybutyrate Enriched with Simvastatin in Bone Regeneration after Tooth Extraction (Experimental Study)
Physiological resorption of bone tissue after tooth extraction leads to a decrease in the volume of bone tissue available for implantation and makes it difficult to install dental implants. Preservation of the well after tooth extraction is the solution to this problem, with the choice of bone plastic material playing an important role. The development of an “ideal” bone plastic material with osteoinductive properties that promotes reparative bone regeneration remains an urgent task.
The aim of the study was to evaluate the regeneration of bone tissue of the alveolar ridge during implantation of a new osteoinductive bone plastic material containing simvastatin into the wells of extracted teeth in sheep using microcomputer tomography.
Materials and Methods. The study was conducted on 24 adult sheep with a total of 48 teeth removed. 12 wells were filled with material based on poly(3-hydroxybutyrate) (PHB) with simvastatin; 12 wells were filled with PHB-based material without simvastatin, 24 wells were used as a control. Micro-CT was used for comparative analysis of bone tissue formation between the test groups after 3 and 6 months.
Results. The results of the study confirm the positive effect of simvastatin released from the PHB-based osteoplastic material on the volume of the formed bone tissue and the total bone volume in the defect area (BV/TV) and bone mineral density (BMD) 3 and 6 months after surgery.
Conclusion. The study demonstrated that simvastatin, released from the PHB-based osteoplastic material, has an osteoinductive effect, promoting bone tissue regeneration in the wells left after tooth removal. Higher BV/TV and BMD values in the wells indicate better efficacy of the material in terms of regeneration support.
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