Мультифотонная томография и кросс-поляризационная оптическая когерентная томография в диагностике глиальных опухолей головного мозга: пилотное исследование

Развитие хирургии инфильтративно растущих глиом головного мозга тесно связано с внедрением новых технологий интраоперационной диагностики. Наиболее перспективными в отношении определения границ опухолевого роста и оценки степени злокачественности выглядят методы оптического биоимиджинга, обладающие высоким пространственным разрешением: мультифотонная томография (МФТ) и оптическая когерентная томография (ОКТ). Однако для широкого внедрения методов в клиническую практику необходимо выявление точных критериев диагностики на основе получаемых с помощью этих методов данных.

В настоящей работе представлены результаты пилотного параллельного ex vivo исследования образцов глиом — глиобластомы 101.8 крысы, а также опухолей человека различной степени злокачественности — и перифокальной зоны опухолей методами МФТ и кросс-поляризационной ОКТ (КП ОКТ). Полученные данные были сопоставлены с гистологическим описанием структуры тканей для определения эффективности использования обоих методов в нейроонкологической практике.

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Dudenkova V.V., Yashin K.S., Kiseleva E.B., Kuznetsov S.S., Timofeeva L.B., Khalansky A.S., Elagin V.V., Gubarkova E.V., Karabut M.M., Pavlova N.P., Medyanik I.A., Kravets L.Ya., Gladkova N.D. Multiphoton Tomography and Cross-Polarization Optical Coherence Tomography for Diagnosing Brain Gliomas: Pilot Study. Sovremennye tehnologii v medicine 2016; 8(4): 64, https://doi.org/10.17691/stm2016.8.4.09