Значение растворимых молекул клеточной адгезии, метаболитов оксида азота, эндотелина-1 и их ассоциаций как маркеров прогрессирования воспаления при ХОБЛ

Цель исследования — оценить значение содержания метаболитов оксида азота, sICAM-1 и sICAM-3 в сыворотке крови и конденсате выдыхаемого воздуха, сывороточного уровня эндотелина-1 в качестве системных и топических маркеров воспаления у больных с ХОБЛ, и их корреляционные связи с параметрами вентиляционной функции легких.

Материалы и методы. В исследовании принимали участие 91 пациент с ХОБЛ в возрасте от 46 до 67 лет и 21 здоровый некурящий доброволец. Материалом для исследования служили образцы сыворотки крови и конденсата выдыхаемого воздуха.

Результаты. Прогрессирование степени тяжести ХОБЛ сопровождалось увеличением сывороточного содержания молекул sCD50, sCD54, ЭТ-1, а также концентрации метаболитов оксида азота в крови и конденсате выдыхаемого воздуха. У больных ХОБЛ установлены ассоциации параметров вентиляционной функции легких и уровня ЭТ-1, sICAM-1, sICAM-3, ΣNO₂^–/NO₃^–. Выявленные взаимосвязи содержания растворимых молекул адгезии с показателями маркеров нитрозативного стресса и уровнем ЭТ-1 свидетельствуют об их участии в генезе хронического воспаления у пациентов с ХОБЛ.

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