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Иммунотерапия колоректального рака: современное состояние и перспективы (обзор)

Иммунотерапия колоректального рака: современное состояние и перспективы (обзор)

О.И. Кит, Е.Ю. Кириченко, И.А. Новикова, А.Ю. Максимов, С.Ю. Филиппова, А.О. Гранкина, Е.Ю. Златник
Ключевые слова: колоректальный рак; иммунотерапия; моноклональные антитела; адоптоклеточная терапия; противораковая вакцина; цитокины.
2017, том 9, номер 3, стр. 138.

Полный текст статьи

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Иммунотерапия солидных опухолей в настоящий момент находится в фазе интенсивного накопления новых знаний и зарождения новых многообещающих методик. Особенно перспективными видятся исследования в области поиска новых контрольных точек иммунитета, разработки высокоэффективных иммунных адъювантов на основе рекомбинантных вирусов для улучшения результатов применения противораковых вакцин, а также конструирования химерных рецепторов Т-клеток, применяющихся для адоптивной иммунотерапии. Приведены некоторые результаты клинических исследований иммунотерапевтических средств, а также экспериментальных исследований на животных моделях, которые открывают новые перспективы в лечении рака толстой кишки.

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Kit О.I., Kirichenko Е.Y., Novikova I.А., Maksimov А.Y., Filippova S.Y., Grankina А.О., Zlatnik Е.Y. Colorectal Cancer Immunotherapy: Current State and Prospects (Review). Sovremennye tehnologii v medicine 2017; 9(3): 138, https://doi.org/10.17691/stm2017.9.3.18


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